nderstanding the sources of tremor variability in patients with essential tremor, Parkinson’s, and dystonia – a non-invasive study of movement and brain signals

Not Applicable

• Conditions: Essential tremor; Parkinson's disease; dystonia; Nervous System Diseases; Parkinson disease; Dystonia

• Registration Number: ISRCTN56202806
• Lead Sponsor: niversity of Oxford

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-01-16
• Last Update Posted: 4 December 2023
• Study Completion: 2025-03-01

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

1. Patients with Essential Tremor without DBS implants for standard clinical indications
2. Patients with Parkinson's disease and tremor dominant without DBS implants for standard clinical indications
3. Patients with Parkinson's disease and non-tremor dominant without DBS implants for standard clinical indications
4. Patients with Dystonic tremor without DBS implants for standard clinical indications
5. Patients between 25 - 80 years of age
6. Patients have the capacity to give informed consent
7. Patients are MRI safe - i.e. no metal implants, history of working in metal industry etc

Exclusion Criteria

1. Cognitive impairment (judged by the clinician taking consent as not having sufficient mental capacity to understand
the study and its requirements). This is including anyone who, in the opinion of the clinician taking consent is unlikely
to retain sufficient mental capacity for the duration of their involvement in the study
2. Pregnancy
3. Severe claustrophobia
4. Head or neck muscle weakness/fatigue
5. Severe visual impairment

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Regions involved in tremor-related networks imaged with great resolution using portable magnetoencephalography (MEG) during a set of motor tasks inducing tremor amplification and tremor suppression. Key data features include oscillatory power changes associated with different disease states. Measured at a single study visit.

Secondary Outcome Measures

Name	Time	Method
Dynamic oscillatory profile of the non-tremor dominant PD network during movement, measured using using portable magnetoencephalography (MEG) at a single study visit