Magneto-encephalography (MEG) to image modulation of brain activity by Spinal Cord Stimulation (SCS) treatment in chronic pain patients, an explorative study.
- Conditions
- Chronic neuropathic pain10034606
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 28
Inclusion Criteria
A subject must meet all of the following criteria:
- have SCS treatment for chronic pain,
- a stimulator that can be programmed in a cyclic stimulation mode,
- SCS treatment for at least 3 months,
- stable and known response to SCS,
- pulse generator implanted in the lower body,
- capable of participation: travel to the institute, sit in the MEG and answer
questions about pain and other sensations.
Exclusion Criteria
A subject who meets any of the following criteria will be excluded from
participation in this study:
- severe pain that is interfering with the pain that the SCS is used for,
- dental wire or other MEG incompatibility, other than the SCS stimulator.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main parameters are power differences in specific frequency bands and<br /><br>differences in functional coupling between cortical pain processing and<br /><br>attention areas for both fast and slow responders to changes in SCS. The main<br /><br>study parameters will be computed from the differences between resting state<br /><br>MEG recordings after switching SCS ON and OFF. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary study parameters are thalamic and thalamocortical changes in spectral<br /><br>power after switching SCS ON and OFF, and correlations of the effects of SCS on<br /><br>pain intensity perception with cortical modulations in the frequency domain. </p><br>