Early cognitive, social and neural mechanisms that precede clinical onset of ASD in a community sample
- Conditions
- Autism Spectrum Disorder1005716710010118
- Registration Number
- NL-OMON49325
- Lead Sponsor
- Radboud Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 100
High-risk infants
Age between 18 months and 24 months old
At least one of the parents understands and speaks Dutch
Positive screen on the Communication and Social development Signals (CoSoS)
(with a score >=3)
Caregiver and/or well-baby office professional (doctor, nurse) has ASD-specific
concerns about their child
Low-risk infants
Age between 18 months and 24 months old
At least one of the parents understands and speaks Dutch
Negativescreen on the Communication and Social development Signals (CoSoS)
(with a score <3)
Caregiver and/or professional does not have any ASD-specific concerns about the
child
High-risk infants
Diagnosis of epilepsy or history of fits/convulsions in infant (not including
febrile convulsions);
Known presence of genetic syndrome (in proband or infant) clearly related to
ASD (e.g. TSC, FXS, 22q11, 16p11.2, Rett*s)
Presence of known significant uncorrected vision or hearing impairment in
infant (reported to parent by a doctor or health care professional)
Infant was born prematurely (pre 36 weeks)
Infant is looked after by the state (e.g. foster care), or other situation in
which neither birth parent is involved in the infant*s care.
Low-risk infants
Diagnosis of epilepsy or history of fits/convulsions in infant;
Known presence of genetic syndrome (in proband or infant) clearly related to
ASD (e.g. TSC, FXS, 22q11, 16p11.2, Rett*s)
Presence of known significant uncorrected vision or hearing impairment in
infant (reported to parent by a doctor or health care professional)
Infant was born prematurely (pre 36 weeks)
Infant is looked after by the state (e.g. foster care), or other situation in
which neither birth parent is involved in the infant*s care.
Presence of known significant developmental or medical condition in infant
likely to affect brain development or infant*s ability to participate in the
study (e.g. Cerebral Palsy, Down*s syndrome, cystic fibrosis)
Presence of ASD in 1st degree relatives
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p><br /><br>Behavioural<br /><br>Communication and Social development Signals (CoSoS)<br /><br>Social Responsiveness Scale (SRS)<br /><br>Autism Diagnostic Observation Schedule (ADOS-2)<br /><br><br /><br>EEG/Eye-Tracking<br /><br>Amplitude/latency of event-related potentials (ERPs) to visual and auditory<br /><br>stimuli<br /><br>Evaluation of EEG power (time frequency analysis)<br /><br>Location of eye gaze and fixation duration (eye-tracking)</p><br>
- Secondary Outcome Measures
Name Time Method <p>n.a.</p><br>