Comparison Between Continuous Versus Interval Exercise Training in Asthmatic Patients
- Conditions
- Asthma
- Interventions
- Other: Continuous Exercise TrainingOther: Interval Exercise TrainingBehavioral: Education Program
- Registration Number
- NCT02489383
- Lead Sponsor
- University of Sao Paulo General Hospital
- Brief Summary
The treatment of asthma is based in clinical control. However, previous studies have been shown that patients that participate of the programs of regular or aerobic continuous exercise training (CT) presented improvements in the physical conditioning, and quality life, as well as decreased the levels of anxiety and depression, reduced the oxide nitric exhaled and leukocyte migration at the airways and reduced the airway hyperresponsiveness. The regular exercise also is important part in the rehabilitation of other lung disease as well as chronic obstructive pulmonary disease (COPD). Additionally, others studies have been shown the effects of high intensity interval training (IT) in the pulmonary rehabilitation of COPD patients, that after performed IT presented reduction of dyspnea, and increase the physical capacity. In this sense, the impact of IT in the asthmatic patients at the present moment is poorly studied, and necessity of the more investigation to prove the efficiency of this training model for asthma patients.
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- Detailed Description
The present study will compare the impact of IT and CT in patients with moderate or severe asthma, and investigate what is the most efficient and increases the physical capacity, and quality of life and reduces the inflammatory mediators.
Sixty asthmatic adults will be randomly assigned into two groups: CT (Continuous training) or IT (Interval training). CT will have treatment 2x week, 40 min./session, 60-75% of maximum heart rate intensity and IT also 2x week, 40 min./session, 80-140% of the maximum load intensity, both performed in ergometer cycle by 24 weeks.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 60
- Asthma moderate and severe
- Asthma will diagnosed (Global Initiative for Asthma - GINA)
- Body Mass Index (BMI) < 35kg/m2
- Medical Treatment for at least 6 months
- Clinically stable (i.e., no exacerbation or medication changes for at least 30 days)
- Cardiovascular, musculoskeletal or other different chronic lung diseases
- Active cancer
- Pregnant
- Smokers
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Continuous Exercise Training Continuous Exercise Training The interventions of active comparator will be education program and exercise training. Interval Exercise Training Interval Exercise Training The interventions of active comparator will be education program and exercise training. Continuous Exercise Training Education Program The interventions of active comparator will be education program and exercise training. Interval Exercise Training Education Program The interventions of active comparator will be education program and exercise training.
- Primary Outcome Measures
Name Time Method Endurance test After 3 months of intervention Measurements at isotime: at identical work rates before and after training, heart rate, perception exertion and dyspnea.
- Secondary Outcome Measures
Name Time Method Health related quality of life Before and after 3 months os intervention, and after 3 months of follow up Health related quality of life will be assessed by Asthma Quality Life Questionnaire (AQLQ)
Nitric oxide exhaled measurement Before and after 3 months of intervention The level of nitric oxide exhaled (FEno) in the patients with asthma will be quantified with use of the equipment Niox Mino (Niox, Solna, Sweden).
Analysis of cortisol in the serum Before and after 3 months of intervention The level plasmatic of cortisol hormone will be quantified by fluoroimmunoassay by AutoDelfia (Turku, Finland).
Level of physical activity Before and after 3 months of intervention, and after 3 months of follow up The level of Physical activity will be analyzed using a pedometer Yamax model PW 610 (Yamasa, Japan) during 7 consecutive days.
Lung function Before and after 3 months os intervention, and after 3 months of follow up Lung volumes will be assessed by Spirometry
Quantification of Inflammatory mediators Before and after 3 months of intervention The levels of inflammatory mediators interleukin (IL)-4, IL-5, IL-6, IL-8, IL-2, IL-12, IL-17, Interferon gamma (IFN-γ), Tumor necrosis factor alpha (TNF-α), IL-10, and chemokines IL-8, Regulated on Activation, Normal T cell Expressed and Secreted (RANTES), Monocyte Chemoattractant Protein-1 (MCP-1), Monokine induced by gamma interferon (MIG), Interferon gamma-induced protein-10 (IP-10) e Transforming Growing Factor-beta (TGF-b) in the serum will be analyzed by Cytometric bead array (CBA) technique (BD Biosciences, San Jose, California, EUA).
Clinical Control Before and after 3 months os intervention, ans after 3 months of follow up Clinical control will be evaluated by asthma control questionnaire (ACQ)
Level of depression and anxiety Before and after 3 months os intervention, and after 3 months of follow up The symptoms of depression and anxiety will be assessed by Hospital Anxiety and Depression (HAD)
Physical capacity Before and after 3 months os intervention Maximal aerobic capacity (VO2max) will be assessed by Cardiopulmonary exercise test
Trial Locations
- Locations (2)
Hospital das Clínicas da Faculadade de Medicina da USP
🇧🇷São Paulo, Brazil
Physical Therapy, and Clinical Hospital of Sao Paulo University Medical School (HCFMUSP)
🇧🇷Sao Paulo, Brazil