EFFECT OF PENTOXIFYLLINE ON THE TIGHT JUNCTIONS (TJs) OF THE INTESTINAL MUCOSA IN PATIENTS WITH IRRITABLE BOWEL SYNDROME (IBS). - IBS-PTX

Hospital Universitario de Canarias0 个研究点开始时间: 2012年1月11日最近更新: 2012年6月26日

适应症

试验速览

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•P atients from 18 to 65 years old and with capacity to give informed consent.
•The patients with IBS are belong that patients who come to Digestive consultation from our center.
•Patients must have a monitoring at least 6 months before the inclussion.
•Achive the Roma III criterions for IBS (Gastroenterology 2006;130:1377-90) with moderate-severe gravity according to Francis modificated scale.
•Patients could not have any alergic pathology or gastrointestinals illness.
•Women with fertile age no pregnant (proven blood or urine test in visit of selection) and use methods of contraception at least from 14 days before first dose of medicine until 14 days after last dose of medicine.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 59
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range

•Patients can not take Salicylates, NSAIDs, antibiotics,anticholinergic, Opiates or any other medication or product
•use for diarrea sintomatic treathment two weeks before biopsia. Besides, others medications as corticoid, antihistamine or immunosuppressives can not be taken 3 months before the colon biopsia.
•Patients who had recibed radiotherapy or chemotherapy 6 months before the study.
•Alergic reactions to pentoxifiline, pregnancy, kidney or hepatic severe failure or any mental or legal disability to sign informed consent .
•Pregnant or while breastfeeding.
•All cases where medicine in research is contraindicated by medicine technical data

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