How does breathing in extra oxygen during late pregnancy change fetal blood flow and can this be used to help babies with congenital heart defects?

Not Applicable

• Conditions: Other obstetric conditions, not elsewhere classified; Pregnancy and Childbirth

• Registration Number: ISRCTN38470689
• Lead Sponsor: King's College London

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-04-01
• Last Update Posted: 12 July 2021
• Study Completion: 2022-05-31

Recruitment & Eligibility

• Status: Ongoing
• Sex: Female
• Target Recruitment: 200

Inclusion Criteria

1. Women with a pregnancy at 18 weeks or later at the time of scan
2. 18 years of age and over
3. Can read the information sheet and understand the purpose of the study and what it would entail

Exclusion Criteria

All groups
1. Maternal weight > 125kg
2. Maternal claustrophobia
3. Patients in the first trimester of pregnancy
4. Use of any of the following medication: adriamycine, bleomycine, actinomycine, menadion, chlorpromazine, thiordiazine, chloroquine
5. Severe maternal respiratory pathology
6. Unable to give informed consent
7. Contra-indication to MRI

Healthy controls
8. Fetal growth restriction
9. Fetal congenital anomaly
10. Maternal placental insufficiency

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Fetal blood flow in the third trimester of normal pregnancies and those associated with fetal or placental pathologies measured by Ultrasound and Magnetic Resonance Imaging at baseline and with additional temporary oxygen supplementation

Secondary Outcome Measures

Name	Time	Method
<br> 1. Placental volume measured by Magnetic Resonance Imaging at scan timepoint<br> 2. Fetal weight measured by Magnetic Resonance Imaging at scan timepoint<br> 3. Brain tissue volumes measured by Magnetic Resonance Imaging at scan timepoint<br> 4. Changes to placental oxygen environment of normal pregnancies and those associated with fetal or placental pathologies measured by blood oxygen level dependent magnetic resonance imaging at baseline and with additional temporary oxygen supplementation<br> 5. Pregnancy demographic and biometric outcome data, including but not limited to congenital heart diagnosis at birth, gestational age at birth, birth weight, head circumference<br>