Mood, serotonin and social interactio

Completed

Conditions: Depression
Mood disorder
10027946

Registration Number: NL-OMON36285

Lead Sponsor: Rijksuniversiteit Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 40

Inclusion Criteria

Age 18-65 years. At least one first-degree family member with MDD (FH+) or no first- and second-degree family members with MDD (FH-). Willingness to cooperate; to sign written informed consent.

Exclusion Criteria

Any current or past DSM-IV Axis I mood disorder, anxiety disorder, psychotic disorder, eating disorder, or somatoform disorder as determined by SCID-NP interview. Any current substance use disorder. Any past substance dependence. Ongoing medical treatment for a chronic disease, particularly cancer, gastrointestinal disease, phenylketonurea, diabetes, cardiovascular disease, or disease of the liver or kidneys. Not speaking Dutch fluently. Current or past use of neuroleptics, sedative drugs, antidepressants etc. On test days, a positive urine test for drugs of abuse. For women, initiation of hormonal contraceptive treatments <= 3 months prior to screening, or a positive urine test for pregnancy on test days

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary outcome is empathic accuracy measured with an empathic accuracy task<br /><br>(EAT). </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary outcome measures are the amount of behavioural mimicry, speech<br /><br>characteristics, heart rate variability (HRV), scores on the Positive and<br /><br>Negative Affect Schedule (PANAS) and Visual Analogue Scale (VAS). Finally,<br /><br>polymorphisms of genes thought to be related to MDD are analysed.</p><br>