Mid-transverse Process Combined With Erector Spinae Block Versus Paravertebral Plane Block

Not Applicable

Recruiting

• Conditions: Lung Cancer
• Interventions: Procedure: Mid-transverse process to pleura block combined with erector spinae block; Procedure: paravertebral block

• Registration Number: NCT06618599
• Lead Sponsor: Cairo University

Brief Summary

This study aims to compare efficacy of Mid-transverse process to pleura block combined with erector spinae block versus paravertebral plane block in cancer patients undergoing thoracotomy surgeries.

Detailed Description

Thoracic paravertebral block (TPVB) application has also been used in recent years due to the lower incidence of side effects. The erector spinae plane block (ESPB)has been used as a part of multimodal analgesia in recent years. In ESPB is aimed to treat the postoperative pain of the thoracoabdominal region by injecting a local anesthetic into the interfacial area under the erector spinae muscle . ESPB creates an effect that covers the posterior and lateral thorax by affecting the dorsal rami and branches of the spinal nerves . Midtransverse process to pleura (MTP) block is less invasive as the position of the needle in this block is midway between the transverse process' posterior border and the pleura. Due to fenestrations present in the superior costotransverse ligament (SCTL), the drug reaches the paravertebral space

Study Timeline

• Status Verified: 2024-09
• Study First Submitted: 2024-09-26
• Study First Submitted QC: 2024-09-26
• Study Start: 2024-10-01
• Study First Posted: 2024-10-01
• Last Update Submitted: 2024-10-25
• Last Update Posted: 2024-10-29
• Primary Completion: 2025-10-01
• Study Completion: 2025-11-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• lung cancer patients for thoracotomy surgeries.
• Physical status American Society of Anesthesiologists (ASA )II, III.
• Age ≥ 18 and ≤ 65 Years.
• Body mass index (BMI): > 20 kg/m2 and < 35 kg/m2

Exclusion Criteria

• Patient refusal
• physical status ASA IV,
• Age <18 years or >65 years
• BMI < 20 kg/m2 and >35 kg/m2
• Known sensitivity or contraindication to drug used in the study (local anesthetics, opioids).
• History of psychological disorders and/or chronic pain.
• Contraindication to regional anesthesia e.g., local sepsis, pre- existing peripheral neuropathies, and coagulopathy.
• Severe respiratory, cardiac, hepatic or renal disease.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group 1:midtransverse to pleura block combined with erector spinae block	Mid-transverse process to pleura block combined with erector spinae block	Patients received ipsilateral Ultrasound guided midtransverse block with injection of 20 ml bupivacaine 0.25% and ipsilateral Ultrasound guided ESPB block with injection of 20 ml bupivacaine 0.25%
Group 2: paravertebral block	paravertebral block	Patients received ipsilateral Ultrasound guided paravertebral plane block with injection of 30 ml bupivacaine 0.25%.

Primary Outcome Measures

Name	Time	Method
visual analogue score changes during rest and cough for the three groups.	for 24 hours postoperative	the score of visual analogue score, with minimum score of 0 and maximum of 10, with higher scores meaning more severe pain

Trial Locations

Locations (1)

Cairo University; 🇪🇬 Cairo, Egypt