Caries Inhibitory Effect of Nano Silver and Tri Calcium Phosphate Varnishes Among Visually Impaired Children

Not Applicable

Completed

• Conditions: Dental Caries
• Interventions: Drug: Nano silver fluoride varnish and tri calcium phosphate varnish

• Registration Number: NCT06576960
• Lead Sponsor: Hadeer Mohammed Abd El wahab

Brief Summary

Assessment of pH,streptococcus mutants count, lactobacillus count and immunoglobulin A among visually impaired children after nano silver varnish application it tri calcium phosphate phosphate varnish application

Detailed Description

Sixty children will be randomly divided into three equal treatment groups, composed of 20 children each, according to the type of material used as follows:

* Group I: children will receive oral health education and nano silver fluoride varnish.

* Group II: children will receive oral health education and tri calcium phosphate varnish.

* Group III: children will receive oral health education

for all children ,Assessment of pH, streptococcus mutants count, lactobacillus count and immunoglobulin A will be assessed at baseline, one day , 3 months and 6 months after application

Study Timeline

• Study Start: 2022-10-11
• Primary Completion: 2023-04-11
• Study Completion: 2023-04-13
• Status Verified: 2024-08
• Study First Submitted: 2024-08-26
• Study First Submitted QC: 2024-08-28
• Last Update Submitted: 2024-08-28
• Study First Posted: 2024-08-29
• Last Update Posted: 2024-08-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Visually impaired children

Exclusion Criteria

• uncooperative children or children not willing to participate in the study.
• Children with systemic diseases
• Children with bronchial asthma.
• Children who were on antibiotic or medications that might affect oral flora or salivary flow taken within the previous 3 months
• History of fluoride treatment in the past 3-4 weeks.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
nano silver varnish	Nano silver fluoride varnish and tri calcium phosphate varnish	new fluoride varnish
tri calcium phosphate varnish	Nano silver fluoride varnish and tri calcium phosphate varnish	fluoride varnish contain calcium phosphate

Primary Outcome Measures

Name	Time	Method
Salivary PH	6 months	Salivary power of hydrogen at baseline, one month, 3months and six months after intervention
Lactobacillus count	6 months	Count of bacteria at baseline, one day, 3months and six months after intervention
Immunoglobulin A	6months	Level of immunoglobulin A at saliva at baseline, one day, 3months and 6 months after intervention
Salivary streptococcus mutants count	6months	Count of bacteria at baseline, one day, 3months and six months after intervention

Trial Locations

Locations (1)

Faculty of dentistry; 🇪🇬 Tanta, Tanta City, Egypt