Propofol or Midazolam for Sedation and Early Extubation Following Coronary Artery Bypass Graft Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Duration of post-surgery sedation
研究概览
简要总结
Propofol and midazolam are used frequently as sedating agents among patients who undergo coronary artery bypass graft surgery but no study in Pakistan has been done to compare their effectiveness aiming early extubation.
详细描述
Propofol is an intra lipid and alkali phenol chemically it is unrelated to sedative agents or anaesthetic. Midazolam is a banzodiazepen. Most of its properties are similar to diazepam. It is a common practice to use sedatives to provide comfort and decrease "ventilator-asynchrony" in critically ill patients that may require prolonged invasive mechanical ventilation. The other reason to employ sedatives is to reduce the anxiety associated with the inaviseve procedures routinely conducted in the ICU.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
盲法说明
Open label
入排标准
- 年龄范围
- 20 Years 至 20 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients of American Society of Anesthesiologists (ASA) III who were selected for coronary artery bypass graft surgery.
排除标准
- •History of any psychiatric disease.
- •Using antidepressants
- •Alcohol abusers
- •Pregnant women
研究组 & 干预措施
MIdazolam Group
Following surgery Immediately after shifting in ICU, midazolam infusion were administered as 0.25 mg/kg/min.
干预措施: Midazolam (Drug)
结局指标
主要结局
Duration of post-surgery sedation
时间窗: Time in minutes calculated from end of surgery to the time of awakening up to 24 hours in both study groups
Duration of post-surgery sedation following cardiac surgery
Time taken to post-surgery extubation
时间窗: Time taken in minutes from the end of the cardiac surgery to post-surgery extubation up to 1 week duration in both study groups
Time taken from the end of cardiac surgery to post-surgery extubation
次要结局
未报告次要终点
研究者
Shumaila rai
Principal Investigator
Chaudhry Pervaiz Elahi Institute of Cardiology