Acute Liver Injury in Patients With Pneumonia

Not yet recruiting

• Conditions: Acute Liver Injury; Pneumonia
• Interventions: Other: Acute Liver Injury

• Registration Number: NCT06103981
• Lead Sponsor: Assiut University

Brief Summary

Acute liver injury (ALI) is defined as an acute derangement in liver function tests associated with liver-related coagulopathy, in the absence of underlying chronic liver disease.

A subset progress to acute liver failure ,Acute liver failure represent a more severe liver injury results in hepatic encephalopathy

Detailed Description

Acute liver injury is associated with a spectrum of haemostatic changes, including thrombocytopenia and reduced platelet function, reduced plasma levels of many coagulation factors such as factor (F)VII and increased levels of FVIII .

Pneumonia is an acute inflammation of the lower respiratory tract. Lower respiratory tract infection is a major cause of mortality worldwide .Pneumonia is most common at the extremes of life.

In adults, pneumonia can be broadly classified, on the basis of chest radiographic appearance, into lobar pneumonia, bronchopneumonia and pneumonia producing an interstitial pattern.

There is lack of data regarding outcome and hospital stay in patients with pneumonia who develop acute liver injury.

Study Timeline

• Study First Submitted: 2023-08-12
• Status Verified: 2023-10
• Study First Submitted QC: 2023-10-25
• Last Update Submitted: 2023-10-25
• Study First Posted: 2023-10-27
• Last Update Posted: 2023-10-27
• Study Start: 2023-12-01
• Primary Completion: 2025-01-10
• Study Completion: 2025-03-10

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 176

Inclusion Criteria

1. Patients with pneumonia that developed Acute Liver Injury
2. Covid 19 pneumonia
3. Patients With acute liver injury only.

Exclusion Criteria

1. Cancer
2. Immunocompromised patients i.e HIV patients and patients who take immunosuppressive medications.
3. Patients who younger than 18 yrs old
4. pregnancy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Group B	Acute Liver Injury	About 88 patients having pneumonia but did not develop acute liver injury that need observation of the outcome and hospital stay
Group A	Acute Liver Injury	About 88 patients having pneumonia and developed acute liver injury That need observation of the outcome and hospital stay to evaluate acute liver injury impact

Primary Outcome Measures

Name	Time	Method
Impact of Acute liver injury due to Pneumonia	From Hospital admission date to Two Months	Analysis the impact of acute liver injury related to patients with pneumonia on hospital stay (measured by days spent in the hospital).

Secondary Outcome Measures

Name	Time	Method
Patients with Pneumonia only	From Hospital admission date to Two Months	To evaluate the Patients with Pneumonia either developed acute liver injury or not, On Hospital Stay

Trial Locations

Locations (1)

Faculty Of Medicine; 🇪🇬 Assuit, Egypt