Acute Liver Injury in Patients With Pneumonia and Its Impact on Hospital Stay and Outcome
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 176
- 试验地点
- 1
- 主要终点
- Impact of Acute liver injury due to Pneumonia
研究概览
简要总结
Acute liver injury (ALI) is defined as an acute derangement in liver function tests associated with liver-related coagulopathy, in the absence of underlying chronic liver disease.
A subset progress to acute liver failure ,Acute liver failure represent a more severe liver injury results in hepatic encephalopathy
详细描述
Acute liver injury is associated with a spectrum of haemostatic changes, including thrombocytopenia and reduced platelet function, reduced plasma levels of many coagulation factors such as factor (F)VII and increased levels of FVIII .
Pneumonia is an acute inflammation of the lower respiratory tract. Lower respiratory tract infection is a major cause of mortality worldwide .Pneumonia is most common at the extremes of life.
In adults, pneumonia can be broadly classified, on the basis of chest radiographic appearance, into lobar pneumonia, bronchopneumonia and pneumonia producing an interstitial pattern.
There is lack of data regarding outcome and hospital stay in patients with pneumonia who develop acute liver injury.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 68 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with pneumonia that developed Acute Liver Injury
- •Covid 19 pneumonia
- •Patients With acute liver injury only.
排除标准
- •Immunocompromised patients i.e HIV patients and patients who take immunosuppressive medications.
- •Patients who younger than 18 yrs old
结局指标
主要结局
Impact of Acute liver injury due to Pneumonia
时间窗: From Hospital admission date to Two Months
Analysis the impact of acute liver injury related to patients with pneumonia on hospital stay (measured by days spent in the hospital).
次要结局
- Patients with Pneumonia only(From Hospital admission date to Two Months)
研究者
Beshoy Yousef Boles Abdelmalak
Resident
Assiut University