Liver Function Abnormalities in Patients With Acute Heart Failure

Not yet recruiting

• Conditions: Acute Heart Failure

• Registration Number: NCT06491628
• Lead Sponsor: Sohag University

Brief Summary

The aim of this study is to evaluate liver function test abnormalities and to identify associated cardiac and non cardiac factors mediating hepatic impairment in acute heart failure patients

Detailed Description

Cardiac failure has a negative impact on the function of all parenchymatous organs, based both on the low organ perfusion in the left-sided failure and on the venous congestion in the right-sided failure.

The pathophysiology of acute heart failure (AHF) is complex and not fully understood. It has been hypothesized that an episode of acute decompensation affects not only the cardiovascular system itself, but may also deteriorate the function of other organs, c ausing serious clinical consequences. Liver involvement has been mostly described and investigated in patients with chronic HF.

Liver enzyme alterations are usually classified as relating predominantly to liver cell necrosis (signified by transaminase elevations) or predominantly to cholestasis (signified by elevated alkaline phosphatase (AP) level).

Study Timeline

• Status Verified: 2024-07
• Study Start: 2024-07-01
• Study First Submitted: 2024-07-01
• Study First Submitted QC: 2024-07-01
• Last Update Submitted: 2024-07-08
• Study First Posted: 2024-07-09
• Last Update Posted: 2024-07-10
• Primary Completion: 2025-07
• Study Completion: 2025-08

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• patients aged 18 yrs or older presenting with AHF

Exclusion Criteria

• Congenital heart disease
• acute and chronic liver diseases

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Liver function abnormalities in patients with acute heart failure in Sohag University Hospitals	baseline	assessment the LFTs abnormalities and factors mediating hepatic impairment in patients with AHF

Secondary Outcome Measures

Name	Time	Method
Liver function abnormalities in patients with acute heart failure in Sohag University Hospitals	1 year	assessment the LFTs abnormalities and factors mediating hepatic impairment in patients with AHF

Trial Locations

Locations (1)

Sohag university; 🇪🇬 Sohag, Egypt