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Clinical Trials/NCT02041637
NCT02041637
Completed
Not Applicable

Unknown Cause of Acute Liver Failure: Determination of Early Mortality Predictive Factors

Assistance Publique - Hôpitaux de Paris1 site in 1 country72 target enrollmentJune 2013
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ConditionsLiver FailureUnknown Etiology

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Liver Failure
Sponsor
Assistance Publique - Hôpitaux de Paris
Enrollment
72
Locations
1
Primary Endpoint
mortality
Status
Completed
Last Updated
9 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

The purpose of the study is to evaluate the outcome and to determine predictive factors of patients admitted in a context of acute liver failure without identified cause.

Detailed Description

Methodology: Multicentric French national cohort with prospective collection of data and constitution of biobank, in patients hospitalized in a context of acute liver failure without known cause at admission. Follow-up during 3 months for each patients. The primary objective is to determine predictive factors of early mortality. This study is an observational cohort and patients will received standard care during the follow-up.

Registry
clinicaltrials.gov
Start Date
June 2013
End Date
January 2017
Last Updated
9 years ago
Study Type
Observational
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • •Acute liver failure defined by a PT\<50% or INR\>1.5;
  • •with or without hepatic encephalopathy;
  • •without cause identified at admission, and non A non B hepatitis;
  • •age\>18 year old;
  • •signed an informed consent.

Exclusion Criteria

  • •chronic liver disease;
  • •Patient under guardianship

Outcomes

Primary Outcomes

mortality

Time Frame: At 3 months

Secondary Outcomes

  • Overall survival rate(At 3 months)
  • post-transplant mortality rate(At 3 months)
  • Liver transplantation rate(At 3 months)

Study Sites (1)

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