Intra-articular Dexamethasone vs Intra-articular Dexamedetomidine
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- pain free time
研究概览
简要总结
Pain relief in knee Arthroscopic Surgery is essential for rapid recovery of function.
详细描述
Intra-articular analgesia is useful in reducing patients' postoperative disability. It anticipates and prevents the onset of pain, and helps avoid the need for additional drugs. Usually it is possible to reach good analgesia in the immediate postoperative period by the administration of analgesic drugs. Recently, intra-articular administration of different anaesthetic substances with a local action (e.g. bupivacaine) has been introduced in clinical practice. The aim of the administration of these substances should not be the reduction of postoperative pain, but its prevention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients scheduled for knee arthroscopy under spinal anaesthesia
排除标准
- •Diabetes Mellitus
- •Contraindication to spinal anesthesia
- •Patient refusal
研究组 & 干预措施
Dexamethasone
patients will receive intra-articular 8 mg dexamethasone added to 18 mL 0.25% bupivacaine into the knee joint.
干预措施: Dexamethasone (Drug)
Dexmedetomidine
patients will receive intra-articular 1ug/kg dexmedetomidine added to 18 mL 0.25% bupivacaine into the knee joint.
干预措施: Dexmedetomidine (Drug)
Control
patients will receive intra-articular 18 mL 0.25% bupivacaine and 2mL isotonic saline into the knee joint.
干预措施: Saline (Drug)
结局指标
主要结局
pain free time
时间窗: 48 hours
VAS
次要结局
未报告次要终点
研究者
Seham Mohamed Moeen Ibrahim
MD
Assiut University