Impact of Dexamethasone Added to Intra-articular Morphine and Bupivacaine for Post-operative Analgesia After Knee Arthroscopy
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- visual analogue score(VAS) at rest and movement
研究概览
简要总结
A randomized double-blinded clinical trial was carried out on 40 patients undergoing knee arthroscopy. Patients were divided randomly into two equal groups. All drugs used were injected intra-articularly at the end of arthroscopy. In the control group, patients were administered 10mg morphine added to bupivacaine 25mg. In the study group, patients were administered 10mg morphine and 8mg dexamethasone added to bupivacaine 25mg. Visual analog score for pain at rest and movement, time to first analgesic request, total analgesic consumption, duration of analgesia and adverse effects were recorded.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American Society of Anesthesiologists (ASA) physical status I and II
- •Scheduled for minor arthroscopic knee surgeries (meniscectomy, chondroplasty, minor ligament repair and diagnostic arthroscopy)
排除标准
- •American Society of Anesthesiologists (ASA) physical status above (II)
- •Undergoing major knee surgeries
- •History of allergies to any of the used drugs
- •History of diabetes mellitus
- •Contraindications of morphine use (e.g. asthmatic patient, chronic obstructive pulmonary disease, and addiction)
研究组 & 干预措施
group M
group M 10mg morphine +0.25% bupivacaine
干预措施: group M (Drug)
group MD
group MD 10mg morphine + 8mg dexamethasone +0.25% bupivacaine
干预措施: group MD (Drug)
结局指标
主要结局
visual analogue score(VAS) at rest and movement
时间窗: first 24 hours post operative
visual analogue score(VAS) will be used to measure pain score (VAS score 0 cm= no pain, VAS score 10 cm = worst possible pain) when the patient is fully conscious (0) and at 2, 4, 6, 8, 10, 12, 18, 24 hours post-operatively
次要结局
- Rescue analgesia time(first 24 hours post operative)
- Total analgesic consumption(first 24 hours post operative)
研究者
Heba Fouad Abd El-Aziz Toulan
Principal Investigator
Ain Shams University