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Impact of Dexamethasone Added to Intra-articular Morphine and Bupivacaine for Post-operative Analgesia After Knee Arthroscopy

Phase 4
Completed
Conditions
Anesthesia
Interventions
Drug: group M
Drug: group MD
Registration Number
NCT04790292
Lead Sponsor
Ain Shams University
Brief Summary

A randomized double-blinded clinical trial was carried out on 40 patients undergoing knee arthroscopy. Patients were divided randomly into two equal groups. All drugs used were injected intra-articularly at the end of arthroscopy. In the control group, patients were administered 10mg morphine added to bupivacaine 25mg. In the study group, patients were administered 10mg morphine and 8mg dexamethasone added to bupivacaine 25mg. Visual analog score for pain at rest and movement, time to first analgesic request, total analgesic consumption, duration of analgesia and adverse effects were recorded.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
40
Inclusion Criteria
  • American Society of Anesthesiologists (ASA) physical status I and II
  • Scheduled for minor arthroscopic knee surgeries (meniscectomy, chondroplasty, minor ligament repair and diagnostic arthroscopy)
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Exclusion Criteria
  • American Society of Anesthesiologists (ASA) physical status above (II)
  • Undergoing major knee surgeries
  • History of allergies to any of the used drugs
  • History of diabetes mellitus
  • Contraindications of morphine use (e.g. asthmatic patient, chronic obstructive pulmonary disease, and addiction)
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Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
group Mgroup Mgroup M 10mg morphine +0.25% bupivacaine
group MDgroup MDgroup MD 10mg morphine + 8mg dexamethasone +0.25% bupivacaine
Primary Outcome Measures
NameTimeMethod
visual analogue score(VAS) at rest and movementfirst 24 hours post operative

visual analogue score(VAS) will be used to measure pain score (VAS score 0 cm= no pain, VAS score 10 cm = worst possible pain) when the patient is fully conscious (0) and at 2, 4, 6, 8, 10, 12, 18, 24 hours post-operatively

Secondary Outcome Measures
NameTimeMethod
Rescue analgesia timefirst 24 hours post operative

Time to first analgesia requirement (considering the extubation is zero time)

Total analgesic consumptionfirst 24 hours post operative

intramuscular diclofenac sodium 75mg will be given as rescue analgesic when VAS ≥ 4. Total diclofenac consumption will be recorded

Trial Locations

Locations (1)

Ain Shams University Hospital

🇪🇬

Cairo, Egypt

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