Impact of Dexamethasone Added to Intra-articular Morphine and Bupivacaine for Post-operative Analgesia After Knee Arthroscopy
- Registration Number
- NCT04790292
- Lead Sponsor
- Ain Shams University
- Brief Summary
A randomized double-blinded clinical trial was carried out on 40 patients undergoing knee arthroscopy. Patients were divided randomly into two equal groups. All drugs used were injected intra-articularly at the end of arthroscopy. In the control group, patients were administered 10mg morphine added to bupivacaine 25mg. In the study group, patients were administered 10mg morphine and 8mg dexamethasone added to bupivacaine 25mg. Visual analog score for pain at rest and movement, time to first analgesic request, total analgesic consumption, duration of analgesia and adverse effects were recorded.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
- American Society of Anesthesiologists (ASA) physical status I and II
- Scheduled for minor arthroscopic knee surgeries (meniscectomy, chondroplasty, minor ligament repair and diagnostic arthroscopy)
- American Society of Anesthesiologists (ASA) physical status above (II)
- Undergoing major knee surgeries
- History of allergies to any of the used drugs
- History of diabetes mellitus
- Contraindications of morphine use (e.g. asthmatic patient, chronic obstructive pulmonary disease, and addiction)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description group M group M group M 10mg morphine +0.25% bupivacaine group MD group MD group MD 10mg morphine + 8mg dexamethasone +0.25% bupivacaine
- Primary Outcome Measures
Name Time Method visual analogue score(VAS) at rest and movement first 24 hours post operative visual analogue score(VAS) will be used to measure pain score (VAS score 0 cm= no pain, VAS score 10 cm = worst possible pain) when the patient is fully conscious (0) and at 2, 4, 6, 8, 10, 12, 18, 24 hours post-operatively
- Secondary Outcome Measures
Name Time Method Rescue analgesia time first 24 hours post operative Time to first analgesia requirement (considering the extubation is zero time)
Total analgesic consumption first 24 hours post operative intramuscular diclofenac sodium 75mg will be given as rescue analgesic when VAS ≥ 4. Total diclofenac consumption will be recorded
Trial Locations
- Locations (1)
Ain Shams University Hospital
🇪🇬Cairo, Egypt