ChiCTR-TRC-09000739CompletedUnknown
Combination of Aprepitant and Dexamethasone to Prevent Postoperative Nausea and Vomiting
Departmental1 site in 1 country320 target enrollmentStarted: February 1, 2006Last updated:
Trial Snapshot
- Phase
- Unknown
- Status
- Completed
- Sponsor
- Enrollment
- 320
- Locations
- 1
- Primary Endpoint
- Complete response (no vomiting, no nausea, no rescue antiemetic)
Study Overview
Brief Summary
Combination of Aprepitant and Dexamethasone to Prevent Postoperative Nausea and Vomiting
Study Design
- Study Type
- Interventional
- Primary Purpose
- 随机平行对照
- Masking
- Double
Eligibility Criteria
- Ages
- 18 to 65 (—)
- Sex
- Male
Inclusion Criteria
- •All women (age 18-65 years) undergoing open gynecologic surgery will be eligible
Exclusion Criteria
- •(1) Patients had preexisting nausea or vomiting;
- •(2) Patients had received opioids or drugs with known antiemetic properties in the 24 hours before surgery;
- •(3) Pregnant patients;
- •(4) Patients with history of esophageal reflux, opioid or alcohol abuse.
Arms & Interventions
Two groups
Aprepitant Immediately before induction of anesthesia Dexamethasone and a combination of Aprepitant and Dexamethasone
Outcomes
Primary Outcomes
Complete response (no vomiting, no nausea, no rescue antiemetic)
Secondary Outcomes
- QoR,FLIE questionnaire, Pain and nausea score
Investigators
Study Sites (1)
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