ChiCTR-IOR-16008191尚未招募不适用
定位連環透顱磁力剌激對認知障礙症患者抑鬱徵狀的療效研究
Research Grant Council1 个研究点 分布在 1 个国家目标入组 60 人开始时间: 1990年1月1日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Depressive symptoms
研究概览
简要总结
定位連環透顱磁力剌激對認知障礙症患者抑鬱徵狀的療效
研究设计
- 研究类型
- 干预性研究
- 主要目的
- 随机平行对照
- 盲法
- Single
入排标准
- 年龄范围
- 60 至 90（—）
- 性别
- All
入选标准
- •Major Neurocognitive Disorder due to AD;
- •Major Vascular Neurocognitive Disorder with small vessel disease;
- •Cornell Scale for Depression in dementia (CSDD) with a rating of 7 or over.
排除标准
- •Past history of bipolar affective disorder or psychosis;
- •Physically frail affecting attendance to TMS sessions;
- •Already attending other brain stimulation therapies;
- •History of major neurological deficit including history of major stroke, transient ischemic attack or traumatic brain injury;
- •Significant communicative impairment.
研究组 & 干预措施
Two groups
Repetitive Transcranial Magnetic Stimulation (rTMS), 10 Hz, 30 trains and 1500 pulses per day, 3 weeks, 5 (once daily) treatment sessions per week, versus Sham Transcranial Magnetic Stimulation
结局指标
主要结局
Depressive symptoms
时间窗: Third week; Sixth week; Twelfth week
次要结局
- Global cognitive function(Third week; Sixth week; Twelfth week)
- Neuropsychiatric symptoms(Third week; Sixth week; Twelfth week)
- Quality of life(Third week; Sixth week; Twelfth week)
- Serum BDNF levels(Third week; Sixth week; Twelfth week)
- Adverse effects(Third week; Sixth week; Twelfth week)
研究者
研究点 (1)
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