Correlation of Anal Acoustic Reflectometry Parameters With Degree of Rectal Intussusception and Prolapse
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 31
- 试验地点
- 1
- 主要终点
- Opening Pressure
研究概览
简要总结
Anal Acoustic Reflectometry (AAR) is a reliable and reproducible technique that has been studied in our department over the last 6 years. Sound waves pass into a balloon placed in the anal canal and are used to measure the cross-sectional area. By gradually increasing and decreasing the pressure in the balloon the investigators can measure the pressure at which the cross-sectional area starts to increase and decrease, and the anal canal starts to open and close. This assessment mimics the natural opening and closing of the anal canal and the effect of squeezing the muscles.
Rectal intussusception occurs when the rectal wall telescopes into itself distally and is termed prolapse when it protrudes through the anal canal. Not all patients will require surgery and, for some, it can lead to debilitating symptoms of constipation, pain and faecal incontinence. Currently, the Oxford grading system through radiological testing is used for classifying severity of rectal intussusception and prolapse; however this does not give us sufficient information about the anal sphincter muscles.
The gold standard investigation of the anal sphincter muscles has been manometry which measures anal canal pressure at rest and during squeeze. However, it has limitations. In previous studies AAR has shown promise in the assessment of faecal incontinence and, that unlike manometry, it has been able to distinguish between different types of incontinence. Thus far, it has not been studied in patients with rectal intussusception and it is hoped that AAR parameters may provide an indication of when rectal intussusception becomes overt rectal prolapse. This can inform the clinician to guide further management of a group of patients with a condition that can have significant impact on quality of life.
详细描述
This an observational study based on not intervention. Patients are grouped depending on grade of prolapse, and all undergo the routine AAR investigation. Patients are grouped solely on differences in pathology already present and not on any intervention.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults over 18 years old
- •Have capacity to consent to the study
- •Patients with pelvic floor dysfunction and symptoms of rectal intussusception and rectal prolapse
排除标准
- •Minors under the age of 18 years old
- •Patients who lack capacity to consent
- •Patients without pelvic floor dysfunction or symptoms of rectal intussusception or rectal prolapse
结局指标
主要结局
Opening Pressure
时间窗: at specific time point of measurement up to 1 hour
The pressure (in cmH20) at which the anal canl just begins to open
次要结局
- Opening Elastance(at specific time point of measurement up to 1 hour)
- Hysteresis(at specific time point of measurement up to 1 hour)
- Closing Elastance(at specific time point of measurement up to 1 hour)
- Squeeze Opening Elastance(at specific time point of measurement up to 1 hour)
- Closing Pressure(at specific time point of measurement up to 1 hour)
- Squeeze Opening Pressure(at specific time point of measurement up to 1 hour)
