Effect of Tranexamic acid on bleeding in cardiac surgery patients
Phase 2
- Conditions
- Ischemic Heart Diseases.Diseases of the circulatory systemI20, I21,
- Registration Number
- IRCT2013071210311N3
- Lead Sponsor
- Vice chancellor for research, Shiraz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 180
Inclusion Criteria
Include criteria: all the patients undergoing first coronary artery bypass graft surgery
Exclude criteria: Emergency patients; Renal failure patients (creatinine>1.5); Anemic patients (Hemoglobin<11); low Cardiac out put patients (<30%); Coagulopathy disorder patients
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Amount of bleeding. Timepoint: 6 hours, 12 hours, 24 hours, 48 hours after surgery. Method of measurement: observing the amount of bleeding in patient chest tubes hourly.;Amount of blood transfusion. Timepoint: During 48 hours after surgery. Method of measurement: noting the amount of blood unite received by patient.
- Secondary Outcome Measures
Name Time Method Qoagulation and blood factors. Timepoint: Befor surgery, immediately after surgery, 24 hours and 48 hours after surgery. Method of measurement: Labratory tests include: Hb, Hct, Bun, Cr, Pt, Ptt, INR.;Intensive care unit staying days. Timepoint: Daily after surgery. Method of measurement: Questionnaire.;Complications (Emboli, Deep Vein Thrombosis, Seizure, Stroke, Infarction, Reexploration, Death). Timepoint: Daily after surgery. Method of measurement: Questionnaire.;Mechanical ventilation time. Timepoint: Hourly after surgery. Method of measurement: Questionnaire.;Chest closure time. Timepoint: Termination of surgery. Method of measurement: Questionnaire.