Post-Resuscitation Pneumothorax - Analysis of Incidence, Risk Factors and Outcome Relevance

Completed

• Conditions: Cardiac Arrest; Resuscitation; Pneumothorax
• Interventions: Procedure: Cardiopulmonary Resuscitation

• Registration Number: NCT06182007
• Lead Sponsor: Auinger, Daniel MD

Brief Summary

In this retrospective study, the investigators seek to investigate the incidence of pneumothorax following possible risk factors, and elucidate its association with outcomes.

Detailed Description

This is a retrospective analysis of routine data, collected by a single Emergency Medical System (EMS). Adult patients (≥18 years) hospitalised after Out-of-Hospital Cardiac Arrest (OHCA) who received chest compressions and underwent chest imaging within 12 hours after hospital admission were included.

Variables and outcomes ascertained are built up of the core elements of the latest version of the Utstein Resuscitation Registry Template for OHCA. This includes sex, age, aetiology of arrest, response times of the first emergency medical service team and emergency physician, witnessed cardiac arrest, bystander CPR/AED, arrest location, first monitored rhythm, defibrillation time, drugs given, reperfusion attempted and target temperature management. Additional variables studied were pre-existing health status represented by the Pre Emergency Status Assessment (PESA), history of lung disease, no-flow-time (time from collapse until initiation of CPR), use of a mechanical chest compression device and prehospital CPR duration.

The primary outcome is incidence of pneumothorax, secondary outcomes are survival to hospital discharge and favourable neurological condition at hospital discharge defined by a cerebral performance category (CPC) of 1 or 2.

Study Timeline

• Study Start: 2020-02-02
• Primary Completion: 2022-10-20
• Study Completion: 2022-12-31
• Status Verified: 2023-12
• Study First Submitted: 2023-12-04
• Study First Submitted QC: 2023-12-13
• Last Update Submitted: 2023-12-13
• Study First Posted: 2023-12-26
• Last Update Posted: 2023-12-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 237

Inclusion Criteria

• Hospitalized after out of hospital cardiac arrest
• Chest compressions received
• Chest imaging within the first 12 hours of admission

Exclusion Criteria

• Traumatic cardiac arrest
• Chest trauma/surgery/pneumothorax one month prior to cardiac arrest

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Pneumothorax	Cardiopulmonary Resuscitation	Patients with a pneumothorax reported from the first chest imaging after hospital admission.
No Pneumothorax	Cardiopulmonary Resuscitation	Patients with no pneumothorax reported from the first chest imaging after hospital admission.

Primary Outcome Measures

Name	Time	Method
Presence of pneumothorax	within 12 hours of admission

Secondary Outcome Measures

Name	Time	Method
Cerebral Performance Category	at hospital discharge (up to 2 months)
Survival	to hospital discharge (up to 2 months)

Trial Locations

Locations (1)

Medical University of Graz; 🇦🇹 Graz, Styria, Austria