Intra- and Inter-fraction Changes in Radiation Therapy

Recruiting

• Conditions: Cancer

• Registration Number: NCT02344121
• Lead Sponsor: Medical College of Wisconsin

Brief Summary

Analysis to quantify intra-fraction, inter-fraction and post-treatment changes in tumor target volumes and surrounding normal organs in radiation therapy.

Detailed Description

The accurate and detailed knowledge of the changes (e.g., anatomically/biologically intra- and inter-fraction changes) to be obtained from this study would allow the research team to determine how Adaptive Radiation Therapy (ART) should be performed for a given tumor site/type. Radiation oncologists then can choose a proper ART strategy for a given tumor type to account for the anatomic/biological intra- and inter-fraction changes, improving accuracy of radiation therapy delivery, and in turn reducing treatment related toxicities and/or improving tumor local control.

Study Timeline

• Study First Submitted: 2014-12-05
• Study Start: 2015-01
• Study First Submitted QC: 2015-01-16
• Study First Posted: 2015-01-22
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-18
• Last Update Posted: 2025-04-23
• Primary Completion: 2027-12-31
• Study Completion: 2028-03-20

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

°Completed radiation therapy

Exclusion Criteria

°Subjects who refuse voluntary participation

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes of volumes from baseline of organs at risk during and after radiation therapy.	2 years	Changes of organs at risk volumes (cm\^3) during and after radiation therapy.

Secondary Outcome Measures

Name	Time	Method
Changes of volumes from baseline or tumors during and after radiation therapy.	2 years	Changes of tumor volumes (cm\^3) during and after radiation therapy.

Trial Locations

Locations (1)

Froedtert Hospital; 🇺🇸 Milwaukee, Wisconsin, United States