Small-Volume Tubes to Reduce Anemia and Transfusion
- Conditions
- Blood Loss Anemia
- Interventions
- Device: Standard-Volume Blood Collection TubesDevice: Small-Volume Blood Collection Tubes
- Registration Number
- NCT03578419
- Lead Sponsor
- Population Health Research Institute
- Brief Summary
STRATUS will evaluate the use of small-volume ("soft-draw") blood collection tubes for laboratory testing in reducing anemia and transfusion in intensive care unit patients without significant adverse consequences. This is a simple, cost-neutral intervention that could improve the quality of patient care and reduce the harms of frequent laboratory testing.
- Detailed Description
Blood sampling can cause significant unnecessary blood loss particularly in the intensive care unit (ICU). Blood loss contributes to anemia which is highly prevalent in the ICU and is associated with major adverse cardiovascular outcomes and death. Red blood cell (RBC) transfusions to correct anemia also have significant health risks.
Using a stepped wedge cluster randomized trial design, the specific aim of the STRATUS study is to evaluate whether the routine use of small-volume blood collection tubes reduces RBC transfusion compared to standard-volume blood collection tubes in adult ICU patients.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 27411
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Control Period Standard-Volume Blood Collection Tubes Standard-Volume Blood Collection Tubes Intervention Period Small-Volume Blood Collection Tubes Small-Volume Blood Collection Tubes ("soft-draw")
- Primary Outcome Measures
Name Time Method RBC Transfusions through study completion, an average of 1.5 years Average number of red blood cell (RBC) units transfused per patient during ICU admission among patients admitted to ICU for 48 hours or longer.
- Secondary Outcome Measures
Name Time Method ICU and hospital length of stay through study completion, an average of 1.5 years Length of stay in the ICU and hospital
ICU and hospital mortality through study completion, an average of 1.5 years Mortality rates in the ICU and hospital
Hemoglobin Concentration through study completion, an average of 1.5 years Change in hemoglobin concentration from ICU admission to ICU discharge adjusted for number of RBC transfusions received
Trial Locations
- Locations (24)
Joseph Brant Hospital
🇨🇦Burlington, Ontario, Canada
University of Manitoba - Health Sciences Centre
🇨🇦Winnipeg, Manitoba, Canada
William Osler Health System - Etobicoke General
🇨🇦Etobicoke, Ontario, Canada
Hamilton General Hospital
🇨🇦Hamilton, Ontario, Canada
Juravinski Cancer Centre
🇨🇦Hamilton, Ontario, Canada
St. Joseph's Hospital
🇨🇦Hamilton, Ontario, Canada
London Health Sciences Centre - University Hospital
🇨🇦London, Ontario, Canada
CHUM - AB cardiothoracic
🇨🇦Montreal, Quebec, Canada
CHUM - EF neuro ICU
🇨🇦Montreal, Quebec, Canada
Maisonneuve-Rosemont
🇨🇦Montreal, Quebec, Canada
Montreal General Hospital
🇨🇦Montréal, Quebec, Canada
Universite de Sherbrooke - Hopital Fleurimont
🇨🇦Sherbrooke, Quebec, Canada
CHU de Quebec - Enfant-Jésus
🇨🇦Québec, Quebec, Canada
Universite de Sherbrooke - Hôtel-Dieu
🇨🇦Sherbrooke, Quebec, Canada
CHU de Quebec - Hotel Dieu
🇨🇦Quebec, Canada
CHUM - CD transplants/surgical ICU
🇨🇦Montreal, Quebec, Canada
William Osler Health System - Brampton Civic
🇨🇦Brampton, Ontario, Canada
St. Catharine's General Hospital
🇨🇦Saint Catherines, Ontario, Canada
Royal Victoria Hospital
🇨🇦Montreal, Quebec, Canada
Institut Universitaire de Cardiologie et de Pneumologie de Québec
🇨🇦Quebec, Canada
Ciuss-McQ-Chaur
🇨🇦Trois-Rivières, Quebec, Canada
London Health Sciences Centre - CCTC
🇨🇦London, Ontario, Canada
Saint John Regional Hospital
🇨🇦Saint John, New Brunswick, Canada
Hôtel-Dieu de Lévis
🇨🇦Lévis, Quebec, Canada