Effects of glucose administration in fear reduction and extinction: Does glucose affect consolidation of extinction learning?
Not Applicable
- Conditions
- In a first phase of the study only healthy participants are studied.
- Registration Number
- DRKS00018933
- Lead Sponsor
- niversität des Saarlandes, Abteilung für Klinische Psychologie und Psychotherapie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
Healthy volunteers
- normal weight (BMI between 18.5 and 26)
- For women: regular usage of hormonal contraceptives
Exclusion Criteria
- Acute or chronic medical/psychiatric problems
- Diabetes
- Previous traumatic experience or acute depressive feelings
- Prolonged intake of medication (exception: contraceptives)
- Participation in pharmacological studies in the last 4 weeks
- Regular consum of nicotine, alcohol or drugs
- Tinnitus
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method - Differences in fear extinction, reinstatement and extinction recall between groups (glucose vs. placebo)<br>- Paradigm used: Differential Fear Conditioning (Acquisition, Extinction, Reinstatement, extinction recall)<br>- Variables of interest: Electrodermal response (EDA), startle reaction (EMG of the orbicularis oculi muscle), heart rate<br>(ECG), subjective ratings of the stimulus (contingency awareness, fear, expectancy).
- Secondary Outcome Measures
Name Time Method - Heart rate variability (HRV) and electrodermal response (EDA) assessed during resting state at different points of the<br>experiment<br>- Questionnaires and subjective ratings (STAI-S, arousal, stress, activation, anxiety and unpleasantness of electroshock)<br>assessed throughout the experiment<br>- Blood glucose after drink consumption, measured with a blood glucose-monitoring device.