Effect of arginine on chronic anal fissure
Phase 3
Recruiting
- Conditions
- chronic anal fissure.Chronic anal fissureK60.1
- Registration Number
- IRCT20190712044182N1
- Lead Sponsor
- Iran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 76
Inclusion Criteria
Chronic Anal Fischer
Fisher in the posterior and anterior areas of the anus
Non-pregnant and lactating women
Age: 18 - 65 years
BMI: 18.5 - 35 kg/m2
Non-specific digestive diseases such as Crohn's disease, Ulcerative colitis, gastrointestinal cancers and etc.
The absence of diseases that fissure can be their complications: tuberculosis, AIDS, syphilis, herpes, leukemia and etc.
No history of malignancy or malignancy in present
No history of heart disease
No history of fissure and hemorrhoid surgery
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Clinical symptoms (bleeding). Timepoint: at the beginning and the end of the study. Method of measurement: Visual Analogue Scale.;Clinical symptoms (pain). Timepoint: at the beginning and the end of the study. Method of measurement: Visual Analogue Scale.;Clinical symptoms (improve ulcer ). Timepoint: at the beginning and the end of the study. Method of measurement: Visual Analogue Scale.
- Secondary Outcome Measures
Name Time Method Quality of life. Timepoint: at the beginning and end of the study. Method of measurement: General Health Survey Short Form-36.;Internal anal sphincter pressure. Timepoint: at the beginning and end of the study. Method of measurement: manometry.