Effect of 4 Liver Fibrosis Tests (PIIINP, CIV, LN, and HA) on the Prognosis of Liver Cirrhosis: A Single-center, Prospective, Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 108
- 试验地点
- 1
- 主要终点
- Death
研究概览
简要总结
Liver biopsy is the reference method for the measurement of liver fibrosis. But it has many limitations, such as sampling error and individual variation in interpreting the results. Currently, serum liver fibrosis markers have been employed as non-invasive diagnosis of liver fibrosis and evaluation of the severity of liver fibrosis. They include laminin (LN), hyaluronic acid (HA), collagen type IV (CIV), and N-terminal propeptide of collagen III (PIIINP). However, few study was conducted to explore the role of these liver fibrosis markers in evaluating the prognosis of liver cirrhosis. Our hypothesis is that LN, HA, CIV, and PIIINP in combination or alone can predict the prognosis of liver cirrhosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients were admitted to our department.
- •Patients were diagnosed with liver cirrhosis.
- •Patients signed the informed consent and agreed to test serum liver fibrosis markers (PIIINP, CIV, LN, and HA).
排除标准
- •Non-cirrhotic patients.
- •Malignancy.
- •Severe cardiopulmonary diseases.
- •Severe infectious diseases.
- •Other diseases with a shortened lifespan.
- •Pregnant and breastfeeding.
- •Poor adherence.
结局指标
主要结局
Death
时间窗: 6-12 months
次要结局
- Hepatic decompensation events(6-12 months)
研究者
Xingshun Qi
Dr.
General Hospital of Shenyang Military Region