Evaluation of the Anticaries Efficacy of Various Dentifrice Formulations Using an In-situ Model
- Conditions
- dental cariesenamel demineralizationOral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon
- Registration Number
- ACTRN12623000381684
- Lead Sponsor
- Procter & Gamble
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 12
Inclusion Criteria
Age range: 18 to 75 years.
Gender: Males and females.
Good general health.
At least 22 natural teeth.
A gum- stimulated whole salivary flow rate at least 1.0 ml/minute and unstimulated whole salivary flowrate at least 0.2 ml/minute. Available for both treatment periods.
The exclusion criteria include:
1) History of adverse or allergic reactions to tin or tin-containing products, arginine or any other ingredients in the toothpaste products;
2) Orthodontic appliances or removable dentures;
3) Veneers, or more than one incisor with an artificial crown;
4) Oral diseases including advanced periodontal disease;
5) Chronic disease such as diabetes or use of medications that cause gum swelling;
6) Untreated decay;
7) Treatment with antibiotics or anti-infl ammatory medicines in the month prior to starting the study;
8) Use of drugs that may interact with the toothpaste slurries or which may aff ect salivary fl ow rate;
9) History of health conditions requiring antibiotic coverage prior to dental treatment;
10) Pregnancy/lactation;
11) Serious infectious disease;
12) Any other medical or dental condition deemed to put the health and wellbeing of you or the research team at risk if you participated in
the study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method