Effects of immunosuppressive agents on innate immunity in renal transplant patients

Completed

• Conditions: pyelonefritis; urinary tract infection; 10004018

• Registration Number: NL-OMON42130
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 105

Inclusion Criteria

Patients have to be older than 18 years
Patients have to be at least 6 month post renal transplant
Clinically stable patients at the time of blood donation (without bacterial infection)
> 3month on CNi + MMF or mTORi + MMF as immunosuppressive regime

Exclusion Criteria

zie vorige

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Expression pattern of TLR4 mediators in cells isolated from blood of renal<br /><br>transplant patients who receive immunosuppressive drugs</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Release of cytokines by ex-vivo stimulated cells with LPS</p><br>