Effect of Prewarming on Microcirculatory Response

Not Applicable

Completed

• Conditions: Coronary Artery Bypass Graft Triple Vessel
• Interventions: Device: prewarming

• Registration Number: NCT02186210
• Lead Sponsor: Seoul National University Hospital

Brief Summary

Intraoperative hypothermia may affect tissue microcirculation and can induce myocardial injury, wound infection, and coagulopathy. During off-pump coronary artery bypass surgery without cardiopulmonary bypass or induced hypothermia, maintenance of normothermia is important for clinical outcome. The investigators hypothesized that prewarming during induction of general anesthesia would reduce drop of body temperature and change of peripheral microcirculation.

Detailed Description

Microcirculatory parameters can be obtained from vascular occlusion test. Among those parameters, recovery slope during vascular occlusion test is known to reflect recruitment of microvasculature in response to hypoxic or ischemic insult. In this study, we will compare the recovery slope during vascular occlusion test between prewarming treatment group and control group.

Study Timeline

• Study Start: 2014-07
• Study First Submitted: 2014-07-04
• Study First Submitted QC: 2014-07-09
• Study First Posted: 2014-07-10
• Status Verified: 2014-08
• Primary Completion: 2015-05
• Study Completion: 2015-05
• Results First Submitted: 2017-03-02
• Results First Submitted QC: 2018-01-29
• Results First Posted: 2018-10-29
• Last Update Submitted: 2019-02-27
• Last Update Posted: 2019-03-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• off-pump coronary artery bypass surgery

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Exclusion Criteria

• refuse to enroll
• cannot undergo vascular occlusion test: anatomical abnormality of both arms, severe peripheral vascular disease, presence of A-V fistula
• preoperative left ventricular ejection fraction < 35%
• preoperative continuous infusion of vasopressor or inotropes
• pregnancy

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
prewarming	prewarming	prewarming during induction of anesthesia

Primary Outcome Measures

Name	Time	Method
Recovery Slope	3 hours after induction of anesthesia	We will compare recovery slope assessed 3 hours after induction of anesthesia to evaluate the effect of prewarming during induction of anesthesia on microcirculation.

Secondary Outcome Measures

Name	Time	Method
Tissue Oxygen Saturation	During the surgery, an average of 4 hours

Trial Locations

Locations (1)

Seoul National University Hospital; 🇰🇷 Seoul, Korea, Republic of