Cognitive remediation therapy in bipolar disorder

Not Applicable

Completed

• Conditions: Topic: Mental Health; Subtopic: Bipolar affective disorder; Disease: Bipolar affective disorder; Mental and Behavioural Disorders; Bipolar 1 disorder

• Registration Number: ISRCTN32290525
• Lead Sponsor: King's College London (UK)

Brief Summary

2016 Protocol article in http://www.ncbi.nlm.nih.gov/pubmed/27472964 protocol 2021 Results article in https://pubmed.ncbi.nlm.nih.gov/32583630/ results (added 26/06/2020) 2021 Results article in https://doi.org/10.1192/bjo.2021.966 Exploratory study (added 10/03/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-02-03
• Study Completion: 2019-03-31
• Last Update Posted: 20 March 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1. Aged 18 to 65 years
2. Confirmed DSM­V diagnosis of bipolar I disorder
3. Those who have been in an euthymic state at two timepoints one week apart, defined by scores of <8 on the Hamilton Rating Scale for Depression and Young Mania Rating Scale at both timepoints

Exclusion Criteria

1. Presence of a substantial neurological/neurodevelopmental disorder
2. Current diagnosis of personality disorder
3. Recent involvement with alcohol or substance abuse
4. Aged under 18 or over 65 years old
5. Severe visual or auditory problems
6. Unable to understand verbal and written instructions in English

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cognitive Performance is measured at baseline, 12 and 24 weeks.

Secondary Outcome Measures

Name	Time	Method
<br> 1. Engagement with the intervention is determined at 12 weeks<br> 2. Level of functioning is measured at baseline 12 and 24 weeks<br> 3. Symptom prevention is measured at baseline 12 and 24 weeks<br>