EF-41/KEYNOTE D58: Phase 3 Study of Optune Concomitant With Temozolomide Plus Pembrolizumab in Newly Diagnosed Glioblastoma

Phase 3

Recruiting

• Conditions: Glioblastoma
• Interventions: Device: Optune® device; Drug: Temozolomide; Drug: Pembrolizumab; Drug: Placebo

• Registration Number: NCT06556563
• Lead Sponsor: NovoCure GmbH

Brief Summary

This is a multicenter, two-arm, randomized, double-blind, placebo-controlled study of Optune® (Tumor Treating Fields at 200 kHz) together with maintenance Temozolomide (TMZ) chemotherapy agent and pembrolizumab compared to Optune® together with maintenance TMZ and placebo in newly diagnosed Glioblastoma (GBM) patients. The primary objective of the study is t...

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2024-08-13
• Study First Submitted QC: 2024-08-13
• Study First Posted: 2024-08-16
• Status Verified: 2024-12
• Study Start: 2024-12
• Last Update Submitted: 2024-12-18
• Last Update Posted: 2024-12-20
• Primary Completion: 2029-04
• Study Completion: 2029-04

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 741

Inclusion Criteria

1. The participant (or legally acceptable representative) has provided documented informed consent for the study.
2. Be ≥ 18 years of age on day of providing informed consent.
3. Participant with new diagnosis of GBM according to World Health Organization (WHO) 2021 Classification.
4. Recovered from maximal debulking surgery (gross total resection, partial resection and biopsy-only patients are all acceptable), Gliadel wafers placement at the time of surgical resection is allowed.
5. Have completed standard adjuvant chemoradiotherapy of radiotherapy (RT) according to local practice (56-64 Gy), and concomitant TMZ chemotherapy.
6. Amenable to treatment with Optune concomitant with maintenance TMZ (150-200 mg/m^2 daily x 5, Q28 days).
7. Have an Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 to 1 assessed within 7 days before randomization.
8. Stable or decreasing dose of corticosteroids (dexamethasone ≤ 2mg or equivalent) for the last 7 days prior to randomization, if applicable.

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Exclusion Criteria

1. Has received prior therapy with an anti-Programmed Cell Death 1 (PD-1), anti- Programmed Cell Death-Ligand 1(PD-L1), or anti Programmed Cell Death-Ligand 2 (PD-L2) agent or with an agent directed to another stimulatory or co-inhibitory T-cell receptor (e.g.Cytotoxic T-Lymphocyte-Associated protein 4 (CTLA-4), OX 40, CD137).
2. Ongoing requirement for >2 mg dexamethasone (or equivalent), due to intracranial mass effect.
3. Has received prior systemic anti-cancer therapy including investigational agents within 4 weeks prior to randomization.
4. Received a live or live-attenuated vaccine within 30 days before the first dose of study intervention. Administration of killed vaccines are allowed.
5. Is currently participating in or has participated in a study of an investigational agent or has used an investigational device within 4 weeks prior to the first study treatment.
6. Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy (in dosing exceeding 10 mg daily of prednisone equivalent) or any other form of immunosuppressive therapy within 7 days prior the first dose of study medication. Has a known additional malignancy that is progressing or has required active treatment within the past 3 years.
7. Has a history of (noninfectious) pneumonitis/interstitial lung disease that required steroids or has current pneumonitis/interstitial lung disease.
8. Early progressive disease after the end of TMZ/RT. If pseudo progression is suspected, additional imaging studies should be performed to rule out true progression.
9. Infratentorial or leptomeningeal disease.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Treatment Group	Optune® device	-
Treatment Group	Pembrolizumab	-
Treatment Group	Temozolomide	-
Control Group	Optune® device	-
Control Group	Temozolomide	-
Control Group	Placebo	-

Primary Outcome Measures

Name	Time	Method
Overall survival	24 months	Overall survival (OS) is defined as the time from randomization to death due to any cause

Secondary Outcome Measures

Name	Time	Method
Progression-Free Survival (PFS) per RANO assessed by investigator	24 months	PFS is defined as the time interval, in months, between randomization and the first documented disease progression per RANO assessed by investigator or death due to any cause, whichever occurs first.; Note: RANO = Response Assessment in Neuro-Oncology
Progression-Free Survival (PFS) per mRANO assessed by investigator	24 months	PFS is defined as the time interval, in months, between randomization and the first documented disease progression per mRANO assessed by investigator or death due to any cause, whichever occurs first.; Note: mRANO = Modified Radiographic Response Assessment in Neuro-Oncology

Trial Locations

Locations (3)

University of Kentucky Medical Center; 🇺🇸 Lexington, Kentucky, United States

Swedish Medical Center; 🇺🇸 Seattle, Washington, United States

UF Health Neuromedicine; 🇺🇸 Gainesville, Florida, United States