A Study on the Brain Mechanism of cTBS in Improving Medication-resistant Auditory Hallucinations in Schizophrenia
- Conditions
- Schizophrenia
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 200
Inclusion Criteria:<br><br> 1. Written informed consent<br><br> 2. 18-45 years old, right-handed<br><br> 3. Meet the diagnostic criteria for schizophrenia according to the Structural Clinical<br> Interview for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition<br> (DSM-V)<br><br> 4. After a sufficient course of antipsychotic treatment (more than 6 weeks, two or more<br> antipsychotic drugs, at least one of which is the second generation of atypical<br> antipsychotic drugs), auditory hallucinations occurred more than 5 times a day for<br> more than 6 months<br><br> 5. Stable antipsychotic medication 4 weeks before and during the treatment (except<br> auditory hallucination symptoms)<br><br>Exclusion Criteria:<br><br> 1. A history of epilepsy, convulsions, stroke or other serious brain diseases<br><br> 2. There are serious infectious diseases, malignant tumors, and severe somatic<br> comorbidity<br><br> 3. Mental retardation, personality disorder and so on<br><br> 4. Contraindications for magnetic resonance imaging<br><br> 5. Diagnose of substance dependence or abuse as primary clinical problem<br><br> 6. Pregnancy<br><br> 7. Participants had received Modified Electraconvulsive Therapy (MECT) or TMS treatment<br> in recent 6 months
Not provided
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Psychotic Symptom Rating Scales-Auditory Hallucination Subscale (PSYRATS-AH);Structural and Function MRI data;Positive and Negative Syndrome Scale (PANSS)
- Secondary Outcome Measures
Name Time Method Repeatable Battery for the Assessment of Neuropsychological Status (RBANS);The Stroop test;Wisconsin Card Sorting Test (WCST)