Low Creatinine Level and Respiratory Failure

Completed

• Conditions: Respiratory Insufficiency; Intensive Care Unit; Muscle Weakness
• Interventions: Diagnostic Test: Serum creatinine levels

• Registration Number: NCT04368325
• Lead Sponsor: Osijek University Hospital

Brief Summary

Low creatinine levels may be a sign of muscle atrophy or weakness, and therefore predictive for respiratory insufficiency in the Intensive care unit (ICU) patients. The investigators compared the outcomes of participants with low creatinine levels with subsequent ICU participants admitted into ICU in the tertiary hospital.

Detailed Description

The investigators have found a total of 46 participants with low creatinine levels and compared their outcome data with a group of participants with normal or high creatinine levels (control group, N=61). Low creatinine was defined as values of ≤40 μmol/L. Demographic data, type of admission (medical vs. surgical), hemoglobin values, CRP, and ventilator days were compared. A statistical analysis was performed using chi square and T-test.

Study Timeline

• Study Start: 2015-05-17
• Primary Completion: 2016-11-04
• Study Completion: 2017-06-16
• Status Verified: 2020-04
• Study First Submitted: 2020-04-24
• Study First Submitted QC: 2020-04-27
• Last Update Submitted: 2020-04-27
• Study First Posted: 2020-04-29
• Last Update Posted: 2020-04-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 107

Inclusion Criteria

• Inclusion criteria for study group was value of ≤40 µmol/L serume creatinine level during hospitalization in ICU from July 2015 to November 2016.

Exclusion Criteria

• Patients who were younger than 18 years

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Study group	Serum creatinine levels	Total of 46 patients with low serum creatinine levels whose values were obtained from the central laboratory with inclusion criteria (\< 40mmol/L)
Control group	Serum creatinine levels	A total of 61 consecutive patients were obtained who were treated in ICU CHC Osijek, according to the date of admission.

Primary Outcome Measures

Name	Time	Method
Length of mechanical ventilation treatment in group with low serume creatinine level	Through study completion, an average of 1 year	The investigators compared length of mechanical ventilation treatment between group with low serume creatinine level and control group

Secondary Outcome Measures

Name	Time	Method
Hemoglobine values in group with low creatinine level	Through study completion, an average of 1 year	The investigators compared hemoglobine values between group with low creatinine level and control group
Number of patients who started nutrition in ICU	Through study completion, an average of 1 year	The investigators compared number of patients between group with low creatinine level and control group who started nutrition in ICU
Number of patients who receive blood products transfusion	Through study completion, an average of 1 year	The investigators compared number of patients who received blood products between group with low creatinine level and control group
White blood cell values in group with low creatinine level	Through study completion, an average of 1 year	The investigators compared white blood cell values between group with low creatinine level and control group
Platelets values in group with low creatinine level	Through study completion, an average of 1 year	The investigators compared platelet values between group with low creatinine level and control group
Length of stay in ICU in group with low serume creatinine level	Through study completion, an average of 1 year	The investigators compared length of stay in ICU between group with low serume creatinine level and control group
Number of patients discharged	Through study completion, an average of 1 year	The investigators compared number of patients who were discharged from intensive care unit to the ward between group with low creatinine level and control group

Trial Locations

Locations (1)

University hospital centre Osijek; 🇭🇷 Osijek, Croatia