Rapid Kidney Function Decline in Older Adults

Completed

• Conditions: Kidney Function Decline; Glomerular Filtration Rate; Urine Albumin-creatinine Ratio; Healthy Aging; Comorbidity; Chronic Kidney Disease

• Registration Number: NCT06765811
• Lead Sponsor: Huashan Hospital

Brief Summary

This observational study investigates whether a single set of GFR and urine albumin-to-creatinine ratio (ACR) thresholds can accurately screen for rapid kidney function decline in different elderly groups.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-07-01
• Primary Completion: 2022-12-25
• Study Completion: 2022-12-25
• Status Verified: 2024-07
• Study First Submitted: 2025-01-05
• Study First Submitted QC: 2025-01-05
• Last Update Submitted: 2025-01-05
• Study First Posted: 2025-01-09
• Last Update Posted: 2025-01-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1539

Inclusion Criteria

1. Age greater than 70 years;
2. GFR data measured at least twice (two years apart) and ACR data measured once (at baseline);
3. A clear record of the cause of the previous visit; from this, people diagnosed with kidney disease were selected, and kidney disease was defined as various primary nephritis, secondary nephropathy, acute kidney injury (AKI), chronic kidney disease, kidney tumors, or a diagnosis of proteinuria alone.
4. Signed informed consent form.

Exclusion Criteria

1. People with missing baseline biochemical data;
2. Outliers in the population indicators, i.e., data deviating from the mean ± three times the standard deviation;
3. Data with significantly abnormal baseline renal function follow-up (abnormally elevated GFR by more than 10% within 2 years or abnormal ACR value as determined by consultation with a senior nephrologist).

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
A ≥30% decline in glomerular filtration rate (GFR) within 2 years, i.e. a rapid decline in renal function	The risk of rapid decline in kidney function in the elderly was assessed during a 2-year follow-up period

Trial Locations

Locations (1)

Huashan hospital, Fudan university; 🇨🇳 Shanghai, Shanghai, China