rinary Tubular Biomarkers For Predicting Kidney Outcomes in Type 2 Diabetes Mellitus: A Prospective Cohort Study

Completed

• Conditions: Urine biomarker, diabetic kidney disease, urine cystatin, urine NGAL, urine angiotensinogen, urine KIM-1; Type 2 diabetes mellitus patients

• Registration Number: TCTR20230317006
• Lead Sponsor: Phramongkutkalo hospital

Brief Summary

GFR decline more than 40%, or development of ESRD/RRT/death showed a clear separation between patients stratified by high compared low baseline urine biomarker concentrations (urinary cystatin-C, angiotensinogen, KIM-1 and NGAL)

Detailed Description

Not available

Study Timeline

• Study Completion: 2023-01-01
• Study Start: 2023-03-17
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 257

Inclusion Criteria

Age more than 18 years
Type 2 diabetes mellitus
Estimated GFR with CKD-EPI equation more than 15 mL/min/1.73 m2
All patients gave their informed consent

Exclusion Criteria

AKI within 12 weeks
Pregnancy
Life expectancy < 1 year
Unwillingness to participate in the study
History of renal, solid-organ, or bone marrow transplantation

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
GFR decline more than 40 7 years ml/min/1.73m2

Secondary Outcome Measures

Name	Time	Method
death 7 years clinical outcome