Predicting treatment success in anxiety disorder patients by use of biomarkers

Completed

Conditions: anxiety
10002861

Registration Number: NL-OMON46417

Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 75

Inclusion Criteria

diagnose of anxiety disorder
enrollment at intensive exposure therapy program at Pro Persona/Onderwaal Nijmegen
cognitive competent, 18-65 years
fMRI compatibility

Exclusion Criteria

History of or current or previous neurological disorders, psychosis or delusional disorders
History of current brain surgery or epilepsy
Pregnancy
Metal parts in the upper body, implants, medical devices or medicinal plasters
Claustrophobia

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>In the fMR session three paradigms will be tested to determine the neural<br /><br>phenotype:<br /><br> prefrontal regulation task<br /><br> salience processing task<br /><br> face processing task<br /><br><br /><br>Therapy evaluation:<br /><br>A therapy evaluation is routinly in place at pro Persona including a<br /><br>questionnaire battery. We will analyze the aquestionnaire data regarding the<br /><br>therapy outcome and relate results to previously determined neural mechanisms<br /><br>in the individual patient.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>questionnaires:<br /><br> FEELE (Emotional Adjustment Questionnaire for Adults, Grob & Horowitz, 2014)<br /><br><br /><br>Biological markers for stress:<br /><br> heart rate<br /><br> skin conductance<br /><br>pupil dilation<br /><br>shoulder muscle tension (MEG) </p><br>