Risk study of pre-neoplastic lesions in the low esophagus

Not Applicable

Completed

• Conditions: Progression of Barrett's esophagus to adenocarcinoma; Cancer; Barrett oesophagus

• Registration Number: ISRCTN12753474
• Lead Sponsor: Hospital Universitário de Santa Maria

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2017-07-30
• Study Start: 2019-02-13
• Last Update Posted: 11 March 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

Request for upper gastrointestinal endoscopy

Exclusion Criteria

1. Oesophageal obstruction
2. Post-oesophagectomy and bariatric surgery patients
3. Projections =3cm
4. Patients under 18 years of age

Study & Design

• Study Type: Other
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Diagnosis of Barrett's esophagus was determined using upper gastrointestinal endoscopy to detect the presence of columnar mucosa in the esophagus in the shape of digitiform projections, or segments that cover the circumference of the esophagus partially or totally.

Secondary Outcome Measures

Name	Time	Method
<br> 1. The number of suspected lesions was determined using upper gastrointestinal endoscopy.<br> 2. The size of suspected lesions was measured using previously laser-graded biopsy clamp with 0.5cm intervals, designed by the author, and divided in three groups of interes: Group 1 - projections up to 0.99cm, group 2 - 1.00 to 1.99cm and group 3 - 2.00 to 2.99cm, and then biopsied following the Seattle Protocol.<br> 3. The number of suspected lesions during endoscopic examination was 81, where 59 subjects (72.8%) did not confirm for Barrett's esophagus after histologic exam, and 22 (27.2%) were confirmed, representing 1.74% of sample total<br>