Prospective Randomized Trial On Radiation Dose Estimates Of CT Angiography In Patients Applying Iterative Image Reconstruction Techniques - The PROTECTION V Study -
Overview
- Phase
- Phase 4
- Intervention
- Not specified
- Conditions
- Coronary Artery Disease
- Sponsor
- Deutsches Herzzentrum Muenchen
- Enrollment
- 400
- Locations
- 1
- Primary Endpoint
- Image quality
- Last Updated
- 14 years ago
Overview
Brief Summary
The objective of this study is to compare a standard coronary CT angiography scan protocol with conventional image reconstruction with a scan protocol using reduced tube current and a new image reconstruction algorithm. The investigators hypothesize that the image quality of the new scan protocol is not inferior, while radiation dose estimates are reduced by around 30%.
Secondary endpoints of the study include quantitative image quality parameters, prevalence of non-diagnostic studies, prevalence of coronary artery plaques and plaque characteristics (calcified, non-calcified, mixed) and prevalence of follow-up examinations.
Investigators
Eligibility Criteria
Inclusion Criteria
- •patients with an indication for a coronary CT angiography (planned evaluation of the coronary arteries)
- •signed informed consent
- •stable sinus rhythm
- •age \> 18 years
Exclusion Criteria
- •known allergy to contrast agents.
- •patients with known coronary artery disease
- •no stable sinus rhythm
- •coronary ct examinations not focussing on coronary arteries
Outcomes
Primary Outcomes
Image quality
Time Frame: 1 month
Compared with a conventional scan protocol the use of a new scan protocol using iterative image reconstruction and reduced tube current is associated with a comparable diagnostic image quality, while the radiation dose estimates are significantly reduced.
Secondary Outcomes
- Quantitative image quality parameters(1 month)
- Prevalence of coronary artery plaques(1 month)
- Prevalence of non-diagnostic examinations(1 month)
- Radiation dose(1 month)
- Prevalence of follow-up examinations(1 month)