Central processing of inflammatory, neuropathic and uremic pruritus

Recruiting

Conditions: L29.9
Chronic pruritus in atopic dermatitis, brachioradial pruritus and uremic pruritus
L30.8
L29.8
Other specified dermatitis
Other pruritus
Pruritus, unspecified

Registration Number: DRKS00015166

Lead Sponsor: niklinik MünsterInstitut für klinische Radiologie

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 180

Inclusion Criteria

Chronic pruritus in atopic dermatitis, brachioradial pruritus, or uremic pruritus
- Healthy age- and gender-matched controls
- Age: = 18 years
- Skin Type I-IV (after Fitzpatrick)

Exclusion Criteria

Taking antipruritic medication Infection at the examination area
Pregnancy or lactation
Metal implants in the body, claustrophobia, wearing ferromagnetic and non-removable jewelery, tattoos or cosmetics, consent, no stroke or severe depression / other mental illnesses or acute, no known strong calcification of the cerebral vessels and if previous imaging findings are present: no abnormal brain structure changes and / or severe volume reduction (atrophy) of the brain

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
fMRT: activation profiles, network maps, volumetric data, and white matter microstructure of the brain in lichenified vs. non-lichenified - vs. healthy skin in patients with pruritus of different entity compared and compared to healthy controls - depending on clinical parameters (in patients)<br>QST (quantitative sensory testing): individual QST parameters - in lichenified vs. non-lichenified vs. healthy skin in patients with pruritus of different entity compared and compared to healthy controls, as well as dependent on clinical symptoms<br>CMP / CIM (conditioned pain/itch modulation): endogenous inhibition (pruritus / pain) in patients with pruritus of different entity compared and compared to healthy controls as well as clinical symptoms. The measurements will be performed on Tuesdays and Wednesdays, lasting one hour each.

Secondary Outcome Measures

Name	Time	Method
Structure data of the brain<br>Difference between cowhage and NaCl control correlation of MRI results<br>(a) with nerve fiber density (data collected in project 2)<br>(b) with clinical pruritus parameters<br>(c) with QST results