Enhancing Operability in a Hypobaric Hypoxic Environment With a Small Oxygen Storage System
- Conditions
- Hypobaric Hypoxemia
- Registration Number
- NCT03365128
- Lead Sponsor
- University of Cincinnati
- Brief Summary
This is a study to validate the efficacy of using a small portable oxygen source to mitigate altitude-induced hypoxia.
- Detailed Description
The purpose of this study is to validate the efficacy of using a small portable oxygen source to mitigate altitude-induced hypoxic events. To do so, the invesitgators propose the following aims:
1. Determine the ability of a portable oxygen storage device to reverse hypobaric hypoxemia in volunteers at altitude.
2. Determine the duration of time that a single portable oxygen container can maintain normoxia in normal volunteers at altitude.
3. Determine the optimum dose and timing of oxygen use to reverse hypobaric hypoxemia.
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 20
- Altitude chamber qualified
- Previous agreement to be approached regarding altitude chamber research
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Elapsed time during which oxygen saturation by pulse oximetry (SpO2) remains above 90% I 15 minutes Elapsed time during which subject's SpO2 remains above 90% after initially reaching or exceeding 94% following exposure to a simulated altitude of 14,000 and after receiving pulse-dosed oxygen
- Secondary Outcome Measures
Name Time Method Elapsed time during which SpO2 remains above 90% II 15 minutes Elapsed time during which subject's SpO2 remains above 90% after initially following exposure to a simulated altitude of 14,000 and after initially (i) reaching SpO2 value of 82-84% or (ii) attaining 85% of maximum predicted heart rate. This is following exercise on a stationary bicycle at a simulated altitude of 10,000 feet and after receiving pulse-dosed oxygen.
Amount of oxygen needed to return SpO2 to sea level value I 15 minutes Amount of oxygen needed to return subject's SpO2 value to 94% (or higher) after exposure to a simulated altitude of 14,000 feet
Amount of oxygen needed to return SpO2 to sea level value II 15 minutes Amount of oxygen needed to return subject's SpO2 value to 94% (or higher) after (i) reaching SpO2 value of 82-84% or (ii) attaining 85% of maximum predicted heart rate. This is following exercise on a stationary bicycle at a simulated altitude of 10,000 feet