Methods for Objective Selection of Competent Sperm
- Conditions
- Sperm Selection
- Interventions
- Other: Negative selection
- Registration Number
- NCT01265329
- Lead Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
- Brief Summary
In spite of the achievements and developement of the assisted reproduction techniques in the last years, there is still an elevated percentage of unsuccessful treatments, needing sometimes repeated attempts to reach pregnancy.
The molecular physiology of sperm is being better characterized, and some reports have demonstrated the implication of different molecular processes in the pathophysiology of male infertility.
Recently, different sperm selection methods have been based on these molecular differences, showing a better quality of the sperm population after selection.
The main objective of this research project is to clinically apply these techniques in order to increase the pregnancy rates per cycle in infertile couples attending assisted reproduction treatments.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 237
MEN:
- >3million sperm after swimming process
WOMEN:
- < 37 YEARS OLD
- NO GYNECOLOGICAL ANOMOLIES
- HORMONAL VALUES WITHIN CLINICAL RANGE
- NONE
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Annexine V negative Negative selection Sperm selection with Annexine V protein
- Primary Outcome Measures
Name Time Method Gestation 14 days Sperm selection and blood sample confirming gestation
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
IVI Valencia
🇪🇸Valencia, Spain