Fragrance allergy and skin tolerability to essential oils

Conditions: Allergic contact dermatitis to fragrances
10001708
10014982

Registration Number: NL-OMON32295

Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 100

Inclusion Criteria

Diagnosed contact allergy to fragrance (mix I and/or II) with a positive patch test (+, ++ or +++ interpreted according to the ICDRG guidelines)
Clinical healthy skin of the back in two preceding weeks
Written informed consent

Exclusion Criteria

Pregnancy or lactation
Age under 18 or above 70
Legally incompetent adults
Topical treatment of immunosuppressives on the back and arms within 7 days before performing patch tests and until finalization
Commercial skin lotions and ointments on the back and arms less than 8 hours before patch testing
Extensive UV exposure of the back and arms in the last 14 days before performing patch tests and until finalization
Usage of systemic immunosuppressive drugs (e.g. prednison, acitretine, adalimumab, efalizumab, etanercept, methoxsaleen, cyclosporine, azathioprine, infliximab and methothrexate)
NB: Medication that reasonably not intervenes with the study procedures (e.g. an antihistaminicum can be used during the study)
Severe illness, defined as life threatening or severely disabling

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary study parameters are reactions regarding the ICDRG guidelines on<br /><br>patchtests, skin irritability tests and a repeated open application test (user<br /><br>test).</p><br>

Secondary Outcome Measures