Effects Of Pulsatile and Non-Pulsatile Cardiopulmonary Bypass Flow On Predictors Of Outcome After Coronary Artery Bypass Graft Surgery
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 60
- 主要终点
- effects of pulsatile versus non-pulsatile perfusion methods in CABG surgeries on arterial lactate level.
研究概览
简要总结
In cardiac operations, high values of blood lactate have been associated with bad outcomes if detected both during CPB and at the arrival in the intensive care unit (ICU) in adult patients. Many studies highlighted the potential role of hyperlactatemia on admission to the ICU as a marker for adverse outcome, and one study linked hyperlactatemia during CPB with postoperative morbidity and mortality. Evidence that both CENTRAL VENOUS SATURATION (ScVO2) and blood lactates during CPB are potential early predictors of morbidity and mortality in adult cardiac operations are still lacking.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •cardiac surgical patients who will undergo isolated elective CABG and fulfill these criteria:
- •Aged 18 years or above.
- •Operated with cardiopulmonary bypass.
排除标准
- •Preoperative lactate level greater than 3 mmol/l.
- •Redo surgery.
- •If the patient will be reoperated during the study time.
- •Preoperative hemoglobin level less than 10 mg/dl.
- •Ejection fraction (EF) of <30%.
- •Renal impairment.
- •Liver impairment.
- •History of stroke and significant carotid artery stenosis.
- •Chronic obstructive or restrictive lung disease.
研究组 & 干预措施
Group (P): Pulsatile flow will be used during CPB
Pulsatile flow will be used during CPB
干预措施: cardiac surgical patients who will undergo isolated elective cardiopulmonary bypass (Procedure)
Group NP: non-pulsatile perfusion.
non-pulsatile perfusion during CARDIOPULMONARY BYPASS
干预措施: CORONARY BYPASS SURGERY USING CARDIOPULMONARY BYPASS (Procedure)
结局指标
主要结局
effects of pulsatile versus non-pulsatile perfusion methods in CABG surgeries on arterial lactate level.
时间窗: 24 hour
Arterila Lactate values (mmol/L).
effects of pulsatile versus non-pulsatile perfusion methods in CABG surgeries on saturation of central venous blood.
时间窗: 24 hour
saturation of central venous blood (percentage)
次要结局
- Length of ICU stay (days)(24 hour)
- The duration of mechanical ventilation (hours).(24 hour)
- Occurrence of major morbidity(72 hours)
研究者
Islam Elbardan
Lecture of anesthesia and surgical intensive care
Alexandria University