Evaluation of Lactate Levels in as a Risk Factor for Posthepatectomy Liver Failure
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 55
- 试验地点
- 1
- 主要终点
- lactate levels (mmol/L) in patients with PHLF
研究概览
简要总结
Major liver surgery is associated with increased incidence of perioperative complications and increased mortality if these are not addressed quickly in a high dependency intensive care unit. Of these, posthepatectomy liver failure (PHLF) represents one of the most important cause of postoperative unfavourable outcome. The present study investigates the correlation between lactate levels and PHLF. Lactate levels were collected at six specific timepoints: preoperative, pre-dissection phase, post-dissection phase, end of surgery and 24-hours and 48-hours in the postoperative period.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients undergoing major liver surgery for primary or secondary tumours
排除标准
- •unsigned patient consent
- •death within 24 hours
- •need for perioperative renal replacement therapy
- •underlying liver disease (e.g. liver cirrhosis)
- •other causes of raised lactate levels (e.g. shock)
结局指标
主要结局
lactate levels (mmol/L) in patients with PHLF
时间窗: early postoperative period (48 hours)
correlation of lactate levels with the diagnosis of PHLF
次要结局
- mortality(30 days mortality)
研究者
Popescu Mihai
Clinical Professor
Institutul Clinic Fundeni