Perioperative Lactate Kinetics in Patient Undergoing Major Liver Surgery

Completed

• Conditions: Liver Failure, Acute

• Registration Number: NCT04512014
• Lead Sponsor: Institutul Clinic Fundeni

Brief Summary

Major liver surgery is associated with increased incidence of perioperative complications and increased mortality if these are not addressed quickly in a high dependency intensive care unit. Of these, posthepatectomy liver failure (PHLF) represents one of the most important cause of postoperative unfavourable outcome. The present study investigates the correlation between lactate levels and PHLF. Lactate levels were collected at six specific timepoints: preoperative, pre-dissection phase, post-dissection phase, end of surgery and 24-hours and 48-hours in the postoperative period.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-01-01
• Primary Completion: 2019-12-31
• Study Completion: 2019-12-31
• Status Verified: 2020-08
• Study First Submitted: 2020-08-10
• Study First Submitted QC: 2020-08-12
• Last Update Submitted: 2020-08-12
• Study First Posted: 2020-08-13
• Last Update Posted: 2020-08-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 55

Inclusion Criteria

• patients undergoing major liver surgery for primary or secondary tumours

Exclusion Criteria

• unsigned patient consent
• death within 24 hours
• need for perioperative renal replacement therapy
• underlying liver disease (e.g. liver cirrhosis)
• other causes of raised lactate levels (e.g. shock)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
lactate levels (mmol/L) in patients with PHLF	early postoperative period (48 hours)	correlation of lactate levels with the diagnosis of PHLF

Secondary Outcome Measures

Name	Time	Method
mortality	30 days mortality	in hospital mortality

Trial Locations

Locations (1)

Fundeni Clinical Institute; 🇷🇴 Bucharest, Romania