Lactate Levels at Beginning of Surgery Correlates With Ki-67 Labeling Index in Brain Tumors
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Evaluate the correlation between Lactate levels and Ki-67 Index
研究概览
简要总结
In neurosurgery, brain tumor patients show increased levels of lactate at the beginning of surgery. This has been related to malignancy. Ki-67 is a cell proliferation index used as a marker of tumor mitotic activity.
This research aims to describe the correlation between lactate levels and the Ki-67 index in patients with brain tumor.
详细描述
Lactate levels are used in the evaluation of perfusion status in critical care. Increases not related to a hypoperfusion state are observed in the patient with brain tumors. These increases have been related to type and tumor grade. This observation does not fully explain the variation within the same tumor grade.
Ki-67 label index is a marker of mitotic activity that can be used as proliferation index. It has been associated with histologic grade and survival rate. Provides a quantitative measure of the tumor proliferation status.
The investigators will perform a retrospective analysis of the clinical charts of patients after brain tumor resection. The study will address the relationship between baseline lactate levels and the proliferation index found in tissues biopsies.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Neurosurgical craniectomy cases
- •June 2017 - February 2018
- •Valid lactate information after anesthesia induction
- •Ki-67 label index informed in biopsies
- •Tumor type information confirmed in biopsies
排除标准
- •Incomplete lactate or Ki-67 index information
结局指标
主要结局
Evaluate the correlation between Lactate levels and Ki-67 Index
时间窗: Within 1 week after data acquisition
Levels of lactate in first blood analysis after anesthesia induction and proliferation index in biopsy results
次要结局
未报告次要终点
研究者
Ricard Valero
Head of Neuroanesthesia. Associated Professor.
Fundacion Clinic per a la Recerca Biomédica