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临床试验/NCT05448521
NCT05448521招募中不适用

Association of Postoperative Lactate Levels With Postoperative Atrial Fibrillation in Patients Undergoing Isolated Coronary Artery Bypass Graft Surgery

Başakşehir Çam & Sakura City Hospital1 个研究点 分布在 1 个国家目标入组 250 人开始时间: 2022年8月15日最近更新:
适应症

试验速览

阶段
不适用
状态
招募中
发起方
入组人数
250
试验地点
1
主要终点
Postoperative atrial fibrillation

研究概览

简要总结

Postoperative atrial fibrillation (POAF) is associated with increased mortality and morbidity in patients undergoing isolated coronary artery bypass grafting (CABG). It has been estimated that 5-40% of CABG patients experience POAF. Advanced age, P wave abnormalities, left atrial dilation, emergency surgery, low left ventricle ejection fraction, low glomerular filtration rate and chronic obstructive pulmonary disease have been reported in the etiology. Predicting which patients would experience POAF following CABG is important since it would allow physicians to apply more focused prophylactic measures. Lactate is the final product of anaerobic glycolysis. Serum lactate level are increased in case of inadequate oxygen delivery to tissues. The investigators aim to assess whether serum lactate levels measured early in the postoperative period could be used as a predictive marker of POAF in adults undergoing isolated CABG.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Undergoing isolated CABG
  • Age >18 years

排除标准

  • Age <18 years
  • Pregnancy
  • History of paroxysmal atrial fibrillation prior to surgery
  • Undergoing concomitant procedures (e.g., CABG + valve surgery)
  • Any preoperative cardiac rhythm other than normal sinus rhythm
  • More than mild cardiac valve stenosis or insufficiency

结局指标

主要结局

Postoperative atrial fibrillation

时间窗: 30 days

New-onset atrial fibrillation occurring in the immediate period after CABG

次要结局

未报告次要终点

研究者

发起方
Başakşehir Çam & Sakura City Hospital
申办方类型
Other Gov
责任方
Principal Investigator
主要研究者

Zeki Temiztürk

Principal Investigator

Başakşehir Çam & Sakura City Hospital

研究点 (1)

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