The effect of FSH administration with HCG at the time of trigger on IVF cycles outcomes

Phase 2

Conditions: Female infertility.
Female infertility,unspecified
N97.9

Registration Number: IRCT2017082724512N5

Lead Sponsor: Deputy of Research and Technology, Shahid Sadoughi University

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: Female

Target Recruitment: 152

Inclusion Criteria

Infertile women who candidate for IVF cycles underwent GnRH antagonist protocol
Fresh embryo transfer cycles

Exclusion Criteria

Women with history of endocrine disorders
serum estradiol>2500pg/ml in day of trigger
Intrauterine abnormality (uterine polyp; uterine myoma)
Severe male factor
Cycle cancellation or changing to intrauterine insemination
A cycle containing preimplantation genetic diagnosis (PGD)
Women who did not undergo embryo transfer due to the freeze-all policy
Donor or surrogate cycle

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Chemical pregnancy. Timepoint: 14 days after transfer. Method of measurement: BHCG test.;Clinical pregnancy. Timepoint: 2 weeks after positive BHCG. Method of measurement: Transvaginal sonography.

Secondary Outcome Measures

Name	Time	Method
Fertilization proportion. Timepoint: Post oocyte retrival. Method of measurement: The number of fertilized oocytes divided by the total number of oocytes.;Oocyte recovery rate. Timepoint: After oocyte retrieval. Method of measurement: The number of retrieved oocytes divided by the number of follicles >10 mm in size counted on the day of trigger.;Oocyte maturity rate. Timepoint: After oocyte retrieval. Method of measurement: the number of metaphase II (MII) oocytes divided by the number of oocytes retrieved.;Fertilization rate. Timepoint: After formation of 2PNs. Method of measurement: the number of 2PNs divided by the total number of MII oocytes.;Implantation rate. Timepoint: After detection of gestational sac in ultrasonography. Method of measurement: the number of intrauterine gestational sacs observed by transvaginal ultrasonography divided by the total number of transferred embryos.