Comparison of the effect of treatment with HCG and recombinant human FSH versus not treatment on improvement of semen parameters in infertile men after surgical repair of varicocele
- Conditions
- Male infertility due to varicocele.Male infertility
- Registration Number
- IRCT201203039014N3
- Lead Sponsor
- Vic-Chancellor of Research and Technology, Hamadan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Male
- Target Recruitment
- 94
Inclusion criteria are: (a) having unilateral or bilateral palpable varicocele; (b) history of infertility for at least one-year; (c) having healthy wife; having abnormal spermogram.
Exclusion criteria are: (a) having no testis in scrotum; (b) having acute urogenital infection; (c) medical history of abnormal function of testis such as: trauma, torsion, cryptorchidism, vas deferens obstruction, abnormal karyotype, diabetes, chemotherapy, any history of surgical treatment on testis, scrotum or pituitary gland; (d) contraindication of FSH such as high level of FSH in serum or uncontrolled dysfunction of thyroid or adrenal glands; (e) BMI>40; (f) substance abuse such as alcohol, narcotics, or anabolic asteroids; (g) testis smaller than 4 mL in ultrasonography; (h) azoospermia (no spermatozoid); (i) using gonadotropin.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The outcome of interest is improvement of the semen parameters including concentration (106/mm2), motility (%), and morphology (%) of spermatozoid. Timepoint: Three months. Method of measurement: Laboratory tests.
- Secondary Outcome Measures
Name Time Method The secondary outcome of interest is the increase in the rate of pregnancy and decrease in the duration of waiting time for pregnancy. Timepoint: One year. Method of measurement: History taking.