The effect of nutritional supplementation as adjunct to exercise training on resting and exercise-induced oxidative stress, muscle function and exercise capacity in severe Chronic Obstructive Pulmonary Disease patients

umico Research B.V. (The Netherlands)0 sites30 target enrollmentAugust 23, 2007

Overview

No summary available.

Registry

who.int

Start Date

August 23, 2007

End Date

TBD

Last Updated

11 years ago

Study Type

Interventional

Sex

All

Sponsor

umico Research B.V. (The Netherlands)

•1\. Diagnosis of COPD according to the American Thoracic Society (ATS) Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines (Forced Expiratory Volume in one second \[FEV1] less than 60% predicted and FEV1/Forced Vital Capacity \[FVC] less than 70% and less than 10% predicted improvement in FEV1 after b2\-agonist inhalation
•2\. Both male and female, age\-range from 40 to 75 years
•3\. No respiratory tract infection or exacerbation of the disease for at least four weeks before the study
•4\. Capable to provide informed consent
•5\. Presence of other chronic diseases is allowed in case the clinical status is stable for at least four weeks before the study

•1\. Inability to perform the incremental cycle ergometer test
•2\. Chronic use of antioxidants or vitamin supplements
•3\. Investigator's uncertainty about the willingness or ability of the patient to comply with the protocol requirements
•4\. Participation in any other studies involving investigational or marketed products concomitantly or within two weeks prior to entry into the study
•5\. Specific allergy or intolerance