Effect Of The Mediterranean Diet On Zonulin And Infertility

Not Applicable

Completed

• Conditions: Infertility Female; Zonulin; Intestinal Permeability; Mediterranean Diet

• Registration Number: NCT07072936
• Lead Sponsor: SINEM BAYRAM

Brief Summary

The goal of this clinical trial is to learn if mediterranean diet works to treat infertility in women. It will also learn about the initial and end of study zonulin levels of mediterranean diet and control group. The main questions it aims to answer are:

* Does mediterranean diet lower the serum zonulin levels of participants?

* Does mediterranean diet improves the treatment success of participants with infertility? Researchers will compare mediterranean to a control group to see if diet works to treat infertility.

Participants will:

* Apply Mediterranean diet or routine diet without energy restriction for 8 weeks

* Visit the clinic once every 4 weeks for checkups and tests

Detailed Description

Not available

Study Timeline

• Study Start: 2024-02-10
• Primary Completion: 2024-05-20
• Study Completion: 2024-08-30
• Status Verified: 2025-01
• Study First Submitted: 2025-01-20
• Study First Submitted QC: 2025-07-09
• Last Update Submitted: 2025-07-09
• Study First Posted: 2025-07-18
• Last Update Posted: 2025-07-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 22

Inclusion Criteria

• Being in the range of 18.5-29.9 kg/m2 BMI
• Having started infertility treatment

Exclusion Criteria

• Having a chronic disease (diabetes mellitus, hypertension, etc.)
• Previous ovarian surgery
• Being diagnosed with PCOS, endometriosis
• Known autoimmune disease
• Thyroid disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
intestinal permeability	From enrollment to the end of treatment at 8 weeks	serum zonulin levels

Secondary Outcome Measures

Name	Time	Method
infertility outcomes	From enrollment to the end of treatment at 8 weeks	number of embryos formed

Trial Locations

Locations (1)

NovaArt; 🇹🇷 Ankara, Turkey